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Primary testosterone and its derivatives are anabolic steroids used in the treatment of osteoporosis and Turner syndrome. They also enhance fast-twitch muscle weight in female rats. The present study examines the effect of an anabolic steroid on craniofacial growth and development in rats. Five-week-old female Sprague-Dawley rats (125) were divided into experimental and control groups. The experimental group was injected subcutaneously with 1 mg nandrolone phenylpropionate in the interscapular region on alternate days, whereas those in the control group were injected with a vehicle, arachis oil. Rats were sacrificed at 60 and 120 days of age. Cephalometric analysis of soft X-ray cephalograms showed that chronic administration of the anabolic steroid, nandrolone phenylpropionate, resulted in: (1) about a 20% increase in body weight, (2) an increase in total skull length, (3) elongation of the maxillary and mandibular incisors, (4) an increase in the depth of the antegonial notch, and (5) downward-forward growth of the viscerocranium against the neurocranium. These results suggest that nandrolone phenylpropionate may accelerate craniofacial growth and/or induce high functional activity of the masticatory muscles in female rats.

In order to explore the growth changes in facial configuration, 160 subjects (80 young adults and 80 children aged 11-12) with normal occlusion were selected for roentgenocephalometric analysis. The present study led to the following conclusions: (a) The ratios of anterior upper to anterior total facial heights, anterior lower to anterior total facial heights, and anterior upper to anterior lower facial heights in both sexes stayed constant around 45, 55, and 81 per cent, respectively. (b) The change in the ratio of the posterior total to anterior total facial heights was mainly due to the greater potentiality of the posterior part of the lower face. (c) The increases of the lower anterior and posterior dental heights were larger than that of the upper anterior and posterior dental heights, respectively. The increases of the upper and lower posterior dental heights were larger than that of the upper and lower anterior dental heights, respectively. (d) On average, the mandibular plane and the occlusal plane tended to rotate forwards with age while the cant of the sella-nasion plane, the Frankfort horizontal plane, and the palatal plane remained fairly unchanged. (e) The saddle angle, the articular angle, and the FNA angle remained relatively stable with age, while the gonial angle and the FNB angle seemed to be age-related. The decrease in the size of the gonial angle might contribute mainly to the flattening tendency of the mandibular growth coincident with general growth. (f) Both the inclination of upper incisor to palatal plane and lower incisor to mandibular plane remained reasonably constant throughout maturation.(ABSTRACT TRUNCATED AT 250 WORDS)

: The purpose of orthognathic surgery is to improve the patient's face and occlusion.Therefore, under having the informed concent of the patient, it is very important to plan and treat for the dento-facial deformity patient. As the situation now stands, our new technique of combining the dento-maxillo facial m odel method and the face-bow transfer method produce satisfactory result.The characteristics or advantages of this technique are as follow 1. Before surgery, we can show the patient their post-surgical predictable face three-dimensionally.2. This method is applicable for all patient planned two jaw surgery.3. This method allows the maxillary segment to be set more simply and easily than previous methods.4. Especially this method is very useful for the patient that prediction of post-surgical face is difficult.

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