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Background: Ultrasonography is the first imaging method to assess splenomegaly. So far, established normal limits of spleen dimensions remain scanty in the Ethiopian population, and the ultrasound data from the previous studies demonstrated that racial differences could affect the splenic volume; this necessitates the establishment of normative data of spleen dimensions for different areas. Subjects and Methods: A cross-sectional prospective study design was performed at the University of Gondar, hospital. The sonographic measurements of spleen length, width, thickness and volume were performed on 380 subjects. In addition, weight of the subjects were measured using standard anthropometric technique. Age and sex were also recorded. By Pearson's product moment correlation coefficients, the relation of spleen dimensions to weight was evaluated. Results: In males, there is a statistically significant positive correlation between subject weight and spleen length (r=0.244, P<0.001), and volume (r=0.164, P<0.05); however, there is no statistically significant correlation with spleen width (r=0.034, P>0.05) and spleen thickness (r=0.136, P>0.05). In females there is a statistically significant positive correlation between the weight of female subject and spleen length (r=0.274, P<0.001), width (r=0.239, P<0.01), thickness (r=0.244, P<0.01), and volume (r=0.335, P<0.0001). Conclusion: The positive correlation is found between the spleen parameters and weight of both the genders in Ethiopian population which has both clinical and forensic importance.

Background. Wilson’s disease is an inherited autosomal recessive disorder of copper metabolism. Clinical signs, biochemical parameters, histologic findings, and/or ATP7B genetic testing are required to diagnose Wilson’s disease. Case Presentation. 25-year-old and 22-year-old young women (siblings) presented to the University of Gondar Hospital, Northwest Ethiopia, with difficulty of keeping balance of 3-year duration and progressive extremity weakness of 5-year duration, respectively. Both siblings had visible ocular Kayser–Fleischer rings, low serum ceruloplasmin level and increased urinary copper content, ultrasound-evidenced cirrhotic liver disease, and axial T2-weighted MRI hyperintensities in basal ganglia, thalamus, and brainstem (midbrain and pons). Diagnosis of Wilson’s disease was established in both patients using a diagnostic scoring system proposed by “8th International Meeting on Wilson Disease and Menkes Disease, Leipzig (2001).” Treatment with D-penicillamine as a chelator and zinc sulphate as a metalothionein-inductor was started. Screening of their family members was recommended. Conclusion. Wilson’s disease, declared to be an orphan disease, requires clinical acumen of physicians and expensive investigation modalities for prompt recognition and is inaccessible as required, lifelong drugs for treatment.

Obstructive congenital anomalies of the female reproductive tract are rare and usually noticed during adolescent period for failure to see menses with cyclic abdominal pain, abdominal mass and local compressive symptoms. It is very rare for such cases to be symptomatic during early childhood from mucous collection. Congenital hydrometrocolpos (an accumulation of watery fluid in the uterus and vagina) that occurs during fetal period is a very rare condition, only with some case reports. The diagnosis is challenging and usually made late which delays the management resulting poor outcome from local compressive symptoms. We present a case diagnosed with huge congenital hydrometrocolpos secondary to low transverse vaginal septum using ultrasound by experienced radiologist and meticulous genital examination in a 5 day old neonate who had abdominal distention and difficult to pass urine since birth where incision of the septum transvaginally and drainage of the fluid was done to relieve symptoms with successful outcome.