Background A cluster of acute respiratory illness, now known as Corona Virus Disease 2019 (COVID-19) caused by 2019 novel coronavirus (SARS-CoV-2), has become a global pandemic. Aged population with cardiovascular diseases are more likely be to infected with SARS-CoV-2 and result in more severe outcomes and elevated case-fatality rate. Meanwhile, cardiovascular diseases have a high prevalence in the middle-aged and elderly population. However, despite of several researches in COVID-19, cardiovascular implications related to it still remains largely unclear. Therefore, a specific analysis in regard to cardiovascular implications of COVID-19 patients is in great need. Methods In this single-centered, retrospective, observational study, 116 patients with laboratory-confirmed COVID-19 were enrolled, who admitted to the General Hospital of Central Theater Command (Wuhan, China) from January 20 to March 8, 2020. The demographic data, underlying comorbidities, clinical symptoms and signs, laboratory findings, chest computed tomography, treatment measures, and outcome data were collected from electronic medical records. Data were compared between non-severe and severe cases. Results Of 116 hospitalized patients with COVID-19, the median age was 58.5 years (IQR, 47.0–69.0), and 36 (31.0%) were female. Hypertension (45 [38.8%]), diabetes (19 [16.4%]), and coronary heart disease (17 [14.7%]) were the most common coexisting conditions. Common symptoms included fever [99 (85.3%)], dry cough (61 [52.6%]), fatigue (60 [51.7%]), dyspnea (52 [44.8%]), anorexia (50 [43.1%]), and chest discomfort (50 [43.1%]). Local and/or bilateral patchy shadowing were the typical radiological findings on chest computed tomography. Lymphopenia (lymphocyte count, 1.0 × 109/L [IQR, 0.7–1.3]) was observed in 66 patients (56.9%), and elevated lactate dehydrogenase (245.5 U/L [IQR, 194.3–319.8]) in 69 patients (59.5%). Hypokalemia occurred in 24 (20.7%) patients. Compared with non-severe cases, severe cases were older (64.0 years [IQR, 53.0–76.0] vs 56.0 years [IQR, 37.0–64.0]), more likely to have comorbidities (35 [63.6%] vs 24 [39.3%]), and more likely to develop acute cardiac injury (19 [34.5%] vs 4 [6.6%]), acute heart failure (18 [32.7%] vs 3 [4.9%]), and ARDS (20 [36.4%] vs 0 [0%]). During hospitalization, the prevalence of new onset hypertension was significantly higher in severe patients (55.2% vs 19.0%) than in non-severe ones. Conclusions In this single-centered, retrospective, observational study, we found that the infection of SARS-CoV-2 was more likely to occur in middle and aged population with cardiovascular comorbidities. Cardiovascular complications, including new onset hypertension and heart injury were common in severe patients with COVID-19. More detailed researches in cardiovascular involvement in COVID-19 are urgently needed to further understand the disease.

Highly robust, swiftly reversible thermochromic nature of a two-dimensional (2D) perovskite of (PDMA)­(CH3NH3) n−1Pb n I3n+1, nominally prepared as n = 2 is found, where PDMA = C6H4(CH2NH3)2. A wide band gap variation from 700 to 430 nm is observed between room temperature and >60 °C under ambient conditions, resulting from moisture absorption and desorption. X-ray diffraction and Fourier-transform infrared spectroscopy are performed to analyze the hydrated and dehydrated states. Furthermore, the (PDMA)­(CH3NH3) n−1Pb n I3n+1 film is demonstrated as an active material for smart windows and thermochromic solar cells, which could lower the inside air temperature in an enclosed space and supply a power conversion efficiency of more than 0.5% at a high ambient temperature, respectively. Overall, we may pave a pathway for exploring the novel phenomena and applications of Dion–Jacobson 2D perovskites.

Glioma is regarded as the most prevalent malignant carcinoma of the central nervous system, and lack of effective treatment. Thus, the development of new therapeutic strategies targeting glioma is of significant clinical importance. In the present study, histone H3K27 demethylase jumonji domain-containing protein 3 (JMJD3) was investigated as target for glioma treatment. The mRNA of JMJD3 was overexpressed in glioblastoma tissues compared to normal brain tissues (P<0.05). The content of JMJD3 was also higher in glioma cells than in human brain microvascular endothelial cell (hCMEC), and the corresponding level of H3K27me3 was decreased (P<0.05). The treatment with JMJD3 specific inhibitor GSK-J4 can increase the content of H3K27me3 in glioma cells, which means the activity of JMJD3 was inhibited. GSK-J4 can inhibit glioma cell proliferation in a concentration dependent and time-dependent manner (P<0.05). GSK-J4 also induced glioma cell apoptosis and inhibited cell migration (P<0.05). But there was no obvious effect of GSK-J4 on hCMEC cells. All together, these data suggest that GSK-J4 has important potential in the gliomas treatment.

Large amounts of data has made neural machine translation (NMT) a big success in recent years. But it is still a challenge if we train these models on small-scale corpora. In this case, the way of using data appears to be more important. Here, we investigate the effective use of training data for low-resource NMT. In particular, we propose a dynamic curriculum learning (DCL) method to reorder training samples in training. Unlike previous work, we do not use a static scoring function for reordering. Instead, the order of training samples is dynamically determined in two ways -loss decline and model competence. This eases training by highlighting easy samples that the current model has enough competence to learn. We test our DCL method in a Transformerbased system. Experimental results show that DCL outperforms several strong baselines on three low-resource machine translation benchmarks and different sized data of

The stability of the surrounding rock is the key problem regarding the normal use of coal mine roadways, and the floor heave of roadways is one of the key factors that can restrict high-yield and high-efficiency mining. Based on the 1305 auxiliary transportation roadway geological conditions in the Dananhu No. 1 Coal Mine, Xinjiang, the mechanism of roadway floor heave was studied by field geological investigation, theoretical analysis, and numerical simulation. We think that the surrounding rock of the roadway presents asymmetrical shrinkage under the original support condition, and it is the extrusion flow type floor heave. The bottom without support and influence of mining are the important causes of floor heave. Therefore, the optimal support scheme is proposed and verified. The results show that the maximum damage depth of the roadway floor is 3.2 m, and the damage depth of the floor of roadway ribs is 3.05 m. The floor heave was decreased from 735 mm to 268 mm, and the force of the rib bolts was reduced from 309 kN to 90 kN after using the optimization supporting scheme. This scheme effectively alleviated the "squeeze" effect of the two ribs on the soft rock floor, and the surrounding rock system achieves long-term stability after optimized support. This provides scientific guidance for field safe mining.Energies 2020, 13, 381 2 of 14 the surrounding rock and the complexity of occurrence in the environment, the distribution law of floor heave deformation is very complex. In view of the mechanism of unsymmetrical floor heave of a mining roadway in a fully mechanized top coal caving face, we put forward corresponding countermeasures to ensure the normal operation and safety of the roadway.In recent years, many experts and scholars have carried out a series of research studies on the mechanism and control of roadway floor heave under different conditions. Sun et al. [9], based on Euler's formula, analyzed the deformation and failure mechanism of different layered rock roadways by the theory of pressure bar stability, Mohr-Coulomb strength criterion, and the deflection failure mechanical model. According to the flexibility of rock mass, he established new mechanical strength parameters to obtain the best support method by studying the change rule of strength parameters and making full use of the stability of the surrounding rock. Sungsoon Mo et al. [10] introduce some of the main floor heave events in the development of the Glencore Bulga Underground plant. Their study indicates that the high horizontal stress of the roadways surrounding rocks and certain types of floor lithology configuration are the reasons for the failures of floor strata. Zhai et al. [11] analyzed that the bottom depressurized trough can effectively control the floor heave, which is beneficial to the long-term stability of the roadway. The surrounding rock of the large deformation chamber is in a stable state after the excavation of the bottom floor decompression trough and the joint support of the bolt and jet. Gong et al. [12] establishe...