In this study, we aimed to compare the healing effect of strontium ranilate(SR) and hypericum perfaratum (HPE) with the healing effect of prednisolone used in the treatment of experimental colit in rats. Method: 30 wistar albino rats were used in the study. Rats were randomly assigned to 5 consecutive groups consisting of 5 rats. Group 1, healthy rats, group 2 colitis but untreated rats. The rats in groups 3, 4, and 5 had colitis and received 160 mg / kg SR, 1mg/kg prednisolone and HP extracts containing 0.3% hiperisine (250 uq / 300 mg) by oral gavage, respectively for seven days. At the end of the seventh day, the colons of the rats were removed and histopathological examination was performed. Results: The histopathological results of the HPE group were statistically worst including the control group. It was observed that the best results in the treatment groups were SR group followed by prednisolone group, respectively.(P<0.05) Conclusions: This study concluded that SR was at least as effective as prednisolone in colitis treatment, but HPE exacerbate colitis-induced inflammation when received by orally.