We propose a novel optical-frequency-comb (OFC) generation scheme based on single-tone modulation and the four-wave mixing (FWM) effect in one single semiconductor optical amplifier (SOA) modulated by a radio frequency (RF) current. A comprehensive broad-band dynamic model, which considers single-tone modulation and the FWM effect, is presented. The simulated results show that, although only one single continuous-wave light is input into the SOA, an OFC with a large number of frequency components can be achieved as a result of single-tone modulation and the FWM effect in the SOA. The number of comb lines and the spectral bandwidth of the OFC increase by raising the amplitude of the RF modulation current. Increasing the input light power can increase the average optical power of the OFC. The frequency interval is tunable within a certain range by tuning the frequency of the RF modulation current injected into the SOA.