Visual tracking problem demands to efficiently perform robust classification and accurate target state estimation over a given target at the same time. Former methods have proposed various ways of target state estimation, yet few of them took the particularity of the visual tracking problem itself into consideration. Based on a careful analysis, we propose a set of practical guidelines of target state estimation for high-performance generic object tracker design. Following these guidelines, we design our Fully Convolutional Siamese tracker++ (SiamFC++) by introducing both classification and target state estimation branch (G1), classification score without ambiguity (G2), tracking without prior knowledge (G3), and estimation quality score (G4). Extensive analysis and ablation studies demonstrate the effectiveness of our proposed guidelines. Without bells and whistles, our SiamFC++ tracker achieves state-of-the-art performance on five challenging benchmarks(OTB2015, VOT2018, LaSOT, GOT-10k, TrackingNet), which proves both the tracking and generalization ability of the tracker. Particularly, on the large-scale TrackingNet dataset, SiamFC++ achieves a previously unseen AUC score of 75.4 while running at over 90 FPS, which is far above the real-time requirement.

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Down syndrome is one of the most common genetic disorders. The distinctive facial features of Down syndrome provide an opportunity for automatic identification. Recent studies showed that facial recognition technologies have the capability to identify genetic disorders. However, there is a paucity of studies on the automatic identification of Down syndrome with facial recognition technologies, especially using deep convolutional neural networks. Here, we developed a Down syndrome identification method utilizing facial images and deep convolutional neural networks, which quantified the binary classification problem of distinguishing subjects with Down syndrome from healthy subjects based on unconstrained two-dimensional images. The network was trained in two main steps: First, we formed a general facial recognition network using a large-scale face identity database (10,562 subjects) and then trained (70%) and tested (30%) a dataset of 148 Down syndrome and 257 healthy images curated through public databases. In the final testing, the deep convolutional neural network achieved 95.87% accuracy, 93.18% recall, and 97.40% specificity in Down syndrome identification. Our findings indicate that the deep convolutional neural network has the potential to support the fast, accurate, and fully automatic identification of Down syndrome and could add considerable value to the future of precision medicine.

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