Physical comfort in urban open public spaces, including acoustic comfort, has been paid increasing attention. The objective of this research is to identify factors that affect acoustic comfort and soundscape in urban open public spaces. In January 2002 a soundscape walk was organized with 50 university students and evaluation on acoustic comfort and sound quality was carried out in four typical urban open public spaces in Sheffield, UK. Both overall acoustic comfort and individual sounds were evaluated, using 28 indices. Objective measurements were made simultaneously. In March–April 2002, 500 interviews were carried out with various users in two selected open public spaces. Semantic differential analysis of the results shows that the description and evaluation of acoustic comfort and soundscape in urban open public spaces is more complicated than that for product sound quality, but it is still possible to identify several major factors including pleasant, timber, content, and evaluation. Based on the analysis, methods for evaluating acoustic comfort and soundscape in urban open public spaces are proposed. [Work supported by Key Action 4 ‘‘City of Tomorrow and Cultural Heritage’’ from the programme ‘‘Energy, Environment and Sustainable Development’’ within the Fifth Framework Programme of the European Commission.]
Purpose-The purpose of this paper is to report on how library and information science (LIS) as a field operationalizes the concept of organizational sustainability for managing digital resources, projects and infrastructures such as digital libraries and repositories over time. It introduces a nine dimensional framework for organizational sustainability in the digital cultural heritage community. Design/methodology/approach-Content analysis of publications from three LIS databases (2000-2015). Findings-Comparing the articles to the nine dimension framework shows that most LIS articles discuss technology, financial or management dimensions. Fewer articles describe disaster planning, assessment or policy dimensions. Research limitations/implications-Three LIS databases might not include all relevant journals, conferences, white papers and other materials. The data set also did not include books; library management textbooks might include useful material on organizational sustainability. Claims about the prevalence of themes are subject to methodological limits of content analysis. Practical implications-Organizations that steward digital collections need to be clear about what they mean when they are referring to organizational sustainability so that they can make appropriate decisions for future-proofing their collections. The analysis would also suggest for a greater need to consider the full range of dimensions of organizational sustainability. Originality/value-By introducing a new nine dimensional framework of organizational sustainability the authors hope to promote more and better conversations within the LIS community about organizational sustainability. The authors hope these conversations will lead to productive action and improvements in the arrangements of people and work necessary to keep digital projects and services going over time, given ongoing challenges.
Achieving the directional and long-range droplet transport on solid surfaces is widely preferred for many practical applications but has proven to be challenging. Particularly, directionality and transport distance of droplets on hydrophobic surfaces are mutually exclusive. Here, we report that drain fly, a ubiquitous insect maintaining nonwetting property even in very high humidity, develops a unique ballistic droplet transport mechanism to meet these demanding challenges. The drain fly serves as a flexible rectifier to allow for a directional and long-range propagation as well as self-removal of a droplet, thus suppressing unwanted liquid flooding. Further investigation reveals that this phenomenon is owing to the synergistic conjunction of multiscale roughness, structural periodicity, and flexibility, which rectifies the random and localized droplet nucleation (nanoscale and microscale) into a directed and global migration (millimeter-scale). The mechanism we have identified opens up a new approach toward the design of artificial rectifiers for broad applications.
Two families of DNA glycosylases (YtkR2/AlkD, AlkZ/YcaQ) have been found to remove bulky and crosslinking DNA adducts produced by bacterial natural products. Whether DNA glycosylases eliminate other types of damage formed by structurally diverse antibiotics is unknown. Here, we identify four DNA glycosylases—TxnU2, TxnU4, LldU1 and LldU5—important for biosynthesis of the aromatic polyketide antibiotics trioxacarcin A (TXNA) and LL-D49194 (LLD), and show that the enzymes provide self-resistance to the producing strains by excising the intercalated guanine adducts of TXNA and LLD. These enzymes are highly specific for TXNA/LLD-DNA lesions and have no activity toward other, less stable alkylguanines as previously described for YtkR2/AlkD and AlkZ/YcaQ. Similarly, TXNA-DNA adducts are not excised by other alkylpurine DNA glycosylases. TxnU4 and LldU1 possess unique active site motifs that provide an explanation for their tight substrate specificity. Moreover, we show that abasic (AP) sites generated from TxnU4 excision of intercalated TXNA-DNA adducts are incised by AP endonuclease less efficiently than those formed by 7mG excision. This work characterizes a distinct class of DNA glycosylase acting on intercalated DNA adducts and furthers our understanding of specific DNA repair self-resistance activities within antibiotic producers of structurally diverse, highly functionalized DNA damaging agents.
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