These data suggest that IGF-IR AS[S]ODN can effectively and specifically inhibit HCC growth in vitro and in vivo. Blockage of IGF-IR expression could be a promising therapeutic approach for the management of patients with HCC.

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy, and commonly associated with activating mutations in the Notch1 pathway.

The domain structure of cast NdFeB magnets has been observed using the Kerr effect, both at room temperature and at temperatures up to the Curie point. The domain structure is typical of strongly uniaxial materials, and no substantial changes in domain size or domain structure are found up to the Curie point. The value of the Curie point has been determined from differential scanning calorimeter measurements over a range of heating and cooling rates, and also from a direct measurement of magnetization at 10 kOe versus temperature. The former method gives an extrapolated value of TC =307.5 °C, and the latter method gives TC =321 °C. The difference is attributed to the fact that one measurement is made at zero field and the other at 10 kOe.

The general behavior of the domain structure in Nd2 Fe14 B as a function of temperature has been reported in an earlier paper [Y. Luo, N. Zhang, and X. Su, Acta Metall. Sin. 23, A136 (1987)]. In order to clarify some details of the temperature variation of domain structure in the basal plane of this material, we have now made observations on a single-phase sample of Nd2 Fe14 B. We find that the optical contrast between antiparallel domains, using the Kerr effect for observation, is approximately proportional to the saturation magnetization; both decrease with increasing temperature. The main basal-plane domains are unchanged by heating, but the supplementary closure domains (cone-shaped reversal domains) change in size and shape, and may even disappear, when the sample is heated above 240 °C. Since the domain nucleation process is to some extent random, the domain pattern is different after each thermal demagnetization cycle above the Curie temperature.