Background:The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a series of clinical symptoms and severe illnesses, including acute respiratory distress syndrome (ARDS) and fatal organ failure. We report the fundamental pathological investigation in the lungs and other organs of fatal cases for the mechanistic understanding of severe COVID-19 and the development of specific therapy in these cases. Methods: The autopsy and pathological investigations of specimens were performed on bodies of two deceased cases with COVID-19. Gross anatomy and histological investigation by Hematoxylin and eosin (HE) stained were reviewed on each patient. Alcian blue/periodic acid-Schiff (AB-PAS) staining and Masson staining were performed for the examinations of mucus, fibrin and collagen fiber in lung tissues. Immunohistochemical staining was performed on the slides of lung tissues from two patients. Real-time PCR was performed to detect the infection of SARS-CoV-2. Flow cytometry analyses were performed to detect the direct binding of S protein and the expression of ACE2 on the cell surface of macrophages. Findings: The main pathological features in lungs included extensive impairment of type I alveolar epithelial cells and atypical hyperplasia of type II alveolar cells, with formation of hyaline membrane, focal hemorrhage, exudation and pulmonary edema, and pulmonary consolidation. The mucous plug with fibrinous exudate in the alveoli and the dysfunction of alveolar macrophages were characteristic abnormalities. The type II alveolar epithelial cells and macrophages in alveoli and pulmonary hilum lymphoid tissue were infected by SARS-CoV-2. S protein of SARS-CoV-2 directly bound to the macrophage via the S-protein-ACE2 interaction. Interpretation: Infection of alveolar macrophage by SARS-CoV-2 might be drivers of the "cytokine storm", which might result in damages in pulmonary tissues, heart and lung, and lead to the failure of multiple organs .

Amid rising environmental concerns, Industry 4.0 and blockchain technology (BCT) are transforming circular economy (CE) practices and prevailing business models. Recognize the same; this study examines the role of blockchain technology in circular CE practices and their impact on eco-environmental performance, which influences organizational performance. The study collects data from 404 enterprises located in Chinese and Pakistani territories, involved in cross-border supply chain operations. Both countries' sample has great relevance due to the China Pakistan Economic Corridor (CPEC), which possesses several positive fallouts in terms of technology spillovers across firms. Using the partial least squares structural equation modeling (PLS-SEM) modeling framework, this study provides three key findings. First, BCT significantly improves the circular economy practices (circular procurement, circular design, recycling, and remanufacturing). Second, CE practices help improve firms'environmental performance and stimulate their financial performance. Third, higher eco-environmental performance significantly boosts organizational performance. This study sets out the foundations for participating countries/firms that simultaneously achieve financial and sustainable goals by integrating blockchain technology in circular economy practices.

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The study aims to examine the potential relationship between public health expenditures, logistics performance indices, renewable energy, and ecological sustainability in Association of Southeast Asian Nations member countries. The study used secondary data, which downloaded from the World Bank website and tested for hypotheses using the structural equation modeling. The results show that the use of renewable energy in logistics operations will improve environmental and economic performance to reduce emissions, whereas environmental performance is negatively correlated with public health expenditures, indicating that greater environmental sustainability can improve human health and economic growth. The results also show that increased public health spending and poor environmental performance undermine economic growth in low efficiency and low labor productivity, thus reducing the speed of economic activity. On the other hand, the use of renewable energy in logistics cannot only improve the sustainability of the environment but also create a better national image and provide better export opportunities in environmentally friendly countries to promote sustainable economic growth. The outcomes of this study will help the policy/decision makers to make the proper planning to their investments for achieving sustainable economic growth.

This article examines the association between green logistics operations, social, environmental and economic indicators of SAARC (South Asian Association for Regional Cooperation) countries. The research used GMM (Generalized Method of Moments) and FGLS (Feasible Generalized Least Squares) two methods to tackle the problems of heterogeneity, serial correlation and heteroskedasticity. The findings show that fossil fuel consumption is at the heart of logistics operations; the more fossil fuel and non-green energy resources that are used, the more negative effects on society and environmental sustainability result from this. A lower quality of transport-related infrastructure and logistics services is negatively correlated with fossil fuel usage, carbon emissions, health expenditure, greenhouse gas emissions and political instability of SAARC countries. Conversely, efficient customs procedures and greater information sharing among supply chain partners increase trade opportunities and also improve environmental sustainability in terms of minimum carbon emissions due to the shorter waiting and queue times involved. Further, the application of green energy resources and green practices can mitigate negative effects on social and environmental sustainability due to better logistics operations while improving financial performance in terms of higher GDP per capita, trade openness and greater export opportunities around the globe. As there is very limited research using green practices relationship with macro-level indicators in current literature, this research will assist both practitioners and policymakers to understand the roles of green supply chain and green logistics in enhancing environmental sustainability, social improvement and economic growth for a better future.