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Tumor on a Chip In article number 2200758, Lu Huang and co‐workers propose a pathomimetic colorectal tumor‐on‐a‐chip (CRT‐chip) that can effectively recapitulate the in vivo dynamic physiology and pathology of primary colorectal cancer (CRC). The cover figure demonstrates the analogy between the CRT‐chips and the in vivo primary CRC. The central channel seeded with epithelial cells mimics the epithelium layer of colorectum. The tumor cells loaded in the microchamber emulate the site‐specific primary CRC. The bottom channel underneath the microchamber recapitulates the in vivo tumor vessels.

The microfluidic platforms have been employed as an effective tool for drug screening, which exhibit the advantages of lower reagent consumption, higher throughput and higher degree of automation. Despite the...

The development of an in vitro colorectal cancer (CRC) model that reconstructs the physiopathological microenvironment of human colorectal cancer shows great potential in accelerating the study of CRC mechanisms and the development of anti-CRC drugs. To this end, a pathomimetic colorectal tumor-on-a-chip (CRT-chip) that can effectively recapitulate the in vivo dynamic physiology and pathology of primary CRC is proposed. It not only allows controllable seeding and cultivation of CRC cells to emulate the site-specific occurrence of primary CRC, but also provides continuous low-speed flows and peristalsis-like deformation on colorectum epithelium to simulate the fluid shearing and peristalsis in human colorectum. Moreover, a channel that transports nutrients to CRC cells is designed specifically to mimic the function of tumor vessels. Based on the pathomimetic CRT-chip, the therapeutic effect of a photothermal anticancer drug was tested and quantified, exhibiting its great potentials in in vitro evaluation of anti-CRC drugs.

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