BackgroundAcute gastrointestinal illness (AGI) is an important public-health problem worldwide. Previous national studies of the incidence of AGI in China were performed decades ago, and detailed information was not available. This study therefore sought to determine the magnitude, distribution, and burden of self-reported AGI in China.MethodsTwelve-month, retrospective face-to-face surveys were conducted in 20 sentinel sites from six provinces between July 2010 and July 2011.ResultsIn total, 39686 interviews were completed. The overall adjusted monthly prevalence of AGI was 4.2% (95% confidence interval, 4.0–4.4), corresponding to 0.56 episodes of AGI per person-year. Rates of AGI were highest in children aged < 5 years. Healthcare was sought by 56.1% of those reporting illness. Of the cases who visited a doctor, 32.7% submitted a stool sample. The use of antibiotics was reported by 49.7% of the cases who sought medical care and 54.0% took antidiarrhoeals. In the multivariable model, gender, age, education, household type, residence, season, province and travel were significant risk factors of being a case of AGI.ConclusionsThis first population-based study in China indicated that AGI represents a substantial burden of health. Further research into the specific pathogens is needed to better estimate the burden of AGI and foodborne disease in China.

Unmanned aerial vehicle (UAV) experiments, multiple datasets from ground-based stations and satellite remote sensing platforms, and backward trajectory models were combined to investigate the characteristics and influential mechanisms of the air pollution episode that occurred in Nanjing during 3–4 December 2017. Before the experiments, the position of the detector mounted on a UAV that was minimally disturbed by the rotation of the rotors was analyzed based on computational fluid dynamics (CFD) simulations. The combined analysis indicated that the surface meteorological conditions—high relative humidity, low wind speed, and low temperature—were conducive to the accumulation of PM2.5. Strongly intense temperature inversion layers and the low thickness of the atmospheric mixed layer could have resulted in elevated PM2.5 mass concentrations. In the early stage, air pollution was affected by the synoptic circulation of the homogenous pressure field and low wind speeds, and the pollutants mainly originated from emissions from surrounding areas. The aggravated pollution was mainly attributed to the cold front and strong northwesterly winds above 850 hPa, and the pollutants mostly originated from the long-distance transport of emissions with northwesterly winds, mainly from the Beijing‒Tianjin‒Hebei (BTH) region and its surrounding areas. This long-distance transport predominated during this event. The air pollution level and aerosol optical depth (AOD) were positively correlated with respect to their spatial distributions; they could reflect shifts in areas of serious pollution. Pollution was concentrated in Anhui Province when it was alleviated in Nanjing. Polluted dust, polluted continental and smoke aerosols were primarily observed during this process. In particular, polluted dust aerosols accounted for a major part of the transport stage, and existed between the surface and 4 km. Moreover, the average extinction coefficient at lower altitudes (<1 km) was higher for aerosol deposition.

All intracellular proteins undergo continuous synthesis and degradation. Chaperone-mediated autophagy (CMA) is necessary to maintain cellular homeostasis through turnover of cytosolic proteins (substrate proteins). This degradation involves a series of substrate proteins including both cancer promoters and suppressors. Since activating or inhibiting CMA pathway to treat cancer is still debated, targeting to the CMA substrate proteins provides a novel direction. We summarize the cancer-associated substrate proteins which are degraded by CMA. Consequently, CMA substrate proteins catalyze the glycolysis which contributes to the Warburg effect in cancer cells. The fact that the degradation of substrate proteins based on the CMA can be altered by posttranslational modifications such as phosphorylation or acetylation. In conclusion, targeting to CMA substrate proteins develops into a new anticancer therapeutic approach.

EGFR-T790M and BRAF V600E are the common resistance mechanisms to EGFRtyrosine kinase inhibitors (TKIs). Standard treatment for the triple mutations of EGFR-19del, T790M, and BRAF V600E is still under debate. Herein, we present a case of therapeutic efficacy of osimertinib and dabrafenib plus trametinib on a 63-year-old man with advanced lung adenocarcinoma. This patient reached a remarkable progression-free survival of 9 months without any serious adverse reaction. At the progression of the disease, C797S mutation in cis was detected by liquid biopsy. Subsequently, brigatinib with cetuximab was administered but no curative effect was observed. Then, therapy was changed to apatinib combined with osimertinib. The subsequent CT scan showed that the lesions reached stable disease (SD), and the survival benefit has been evaluated. This case showed that the combination treatment of osimertinib and dabrafenib plus trametinib might be a great treatment option for NSCLC patients with triple mutations (EGFR-19del/T790M/BRAFV600E).

BackgroundFoodborne diseases are a worldwide public health problem. However, data regarding epidemiological characteristics are still lacking in China. We aimed to analyze the characteristics of foodborne diseases outbreak from 2010 to 2016 in Guangxi, South China.MethodsA foodborne disease outbreak is the occurrence of two or more cases of a similar foodborne disease resulting from the ingestion of a common food. All data are obtained from reports in the Public Health Emergency Report and Management Information System of the China Information System for Disease Control and Prevention, and also from special investigation reports from Guangxi province.ResultsA total of 138 foodborne diseases outbreak occurred in Guangxi in the past 7 years, leading to 3348 cases and 46 deaths. Foodborne disease outbreaks mainly occurred in the second and fourth quarters, and schools and private homes were the most common sites. Ingesting toxic food by mistake, improper cooking and cross contamination were the main routes of poisoning which caused 2169 (64.78%) cases and 37 (80.43%) deaths. Bacteria (62 outbreaks, 44.93%) and poisonous plants (46 outbreaks, 33.33%) were the main etiologies of foodborne diseases in our study. In particular, poisonous plants were the main cause of deaths involved in the foodborne disease outbreaks (26 outbreaks, 56.52%).ConclusionsBacteria and poisonous plants were the primary causative hazard of foodborne diseases. Some specific measures are needed for ongoing prevention and control against the occurrence of foodborne diseases.Electronic supplementary materialThe online version of this article (10.1186/s12889-018-5429-2) contains supplementary material, which is available to authorized users.