Introduction: In aesthetic medicine, the use of hardware technologies occupies an important place. Hardware action on skin includes microfocused ultrasound, radiowave, light and laser methods. The ultimate task of each method consists in improving the condition of skin and its rejuvenation. However, to enhance the clinical efficiency, combined actions have been suggested recently. Objective: To compare the effect of microfocused ultrasound as monotherapy and the combined application thereof with autologous blood cell factors. Methods: For assessing efficiency of the procedures undertaken, the data of ultrasonic scanning of skin were studied, photo documentation was performed, and adapted dermatological indices were used: the dermatological status index (DLQI) and WAM index (wellbeing, activity, mood). Results: According to the research results, ultrasonic skin scanning data were obtained which gave evidence about a more pronounced clinical effect in patients having received the combined application of microfocused ultrasound with autologous blood cell factors. The improvement of qualitative characteristics of skin in the form of a thicker dermal stratum and improved dermal coefficient was observed both in the patients having received monotherapy by microfocused ultrasound and in the group where patients underwent its combined application with autologous blood cell factors. However, the improvement of clinical effect was significantly higher in patients having received the combined application as compared to the microfocused ultrasound monotherapy group, which confirms the synergism of the hardware method and the use of factors of autologous blood cells (thrombocytes). Such manifestations as a significant increase of thickness of epidermis in 6 months in patients having received the microfocused ultrasound monotherapy gives an indirect evidence about the presence of compensated dehydration in reparative processes; this is a norm, but it curbs performance of other stimulations. Photo documentation and the analysis of dermatological indices also correlated with the data of US examination of skin. The pronounced clinical efficiency in the use of combined treatment confirms the synergism of the said two methods aimed at improving the quality of skin. Conclusion: The use of autologous blood cell factors significantly improves clinical results and allows employing other stimulation procedures in the integrated correction (laser technologies, radiofrequency methods) after microfocused ultrasound within the periods of up to 6 months after treatment. Keywords: microfocused ultrasound, ultrasonic scanning of skin, involutional changes of skin, factors of autologous blood cells, aesthetic medicine Yusova et al. / Correction of involutional skin changes using microfocused ultrasound combined with PRP-therapy 2 / 9

Using a combined application of surface and deep fractional ablation allows you to solve a wider range of problems in the correction of aesthetic deficiencies in the case of involute skin changes. The study examined the clinical efficacy of the interference of the superficial and deep fractional ablation on epiflourescent and ultrasonic parameters of the skin. There were 52 patients under observation, who were divided into 2 groups according to the treatment regimen. Surface fractional ablation was performed in group 1, and interference of surface and deep fractional ablation was performed in group 2. The analysis of clinical data and the degree of satisfaction with the procedures showed a more pronounced clinical effect when performing combined exposure.

The study presents data on the impact of the monopolar radiofrequency method on the morphofunctional state of the skin. Patients were observed with various morphotypes of involute skin changes. 49 patients aged 45 to 55 years were observed. All patients were divided into 3 groups depending on the prevailing morphotype of involute skin changes: fine-wrinkled, deformed, and mixed. In all groups, a single exposure was performed using the monopolar radio frequency method according to the approved Protocol of work in the face area. Objective research methods included ultrasound sonography of the epidermis and dermis, adapted dermatological indices of quality of life (DIQ) and SAN (well-being, activity, mood). The results were evaluated 3, 6 and 12 months after the treatment. The obtained data showed that the high-frequency radio-wave method is more effective in deformational and mixed types of aging compared to small-scale wrinkling.

Materials and methods. 22 patients with fibromyalgia symptom complex were studied. The treatment proposed by the Protocol therapy skin triggers the back botulinum neurotoxin in very low doses. The results of the study revealed a pronounced clinical efficacy of Botulinum neurotoxin A on the daily functioning of patients and their psycho-emotional status: normalization of sleep, reduced fatigue, a marked reduction in psychovegetative disorders and the absence of pain manifestations, as well as a decrease in the tendency to edema.