The fastest development of technologies encourages computer multimedia-oriented education. Nowadays, information technologies create human basic abilities. College English teaching mode reform based on computer multimedia is the aim of the paper. Generally, computer multimedia technologies oriented college English education merging pictures, videos, audio, vocabulary, and animation. We described the development of multimedia in English teaching mode, applications of college English teaching, a novel model of foreign language teaching in the classroom and a computer, computerized English language teaching method TPACK design, and the latest architecture of college English language teaching based on computers in this paper. We are discussing face-to-face teaching, language lab autonomous learning room, network teaching area in multimedia, and network teaching circumstances in this paper. This paper evaluated wireless communication’s range, challenges facing college English teaching, comparative analysis of attitude, comparative analysis of curriculum, and comparative analysis of technology. We express that, from the year 2000 to the present, the technologies in wireless communications with computer multimedia are developing in the range of wireless communication.