Manganese (Mn) has attracted widespread attention due to its low-cost, nontoxicity, and valence-rich transition. Various Mn-based nanomaterials have sprung up and are employed in diverse fields, particularly Mn-based nanozymes, which combine the physicochemical properties of Mn-based nanomaterials with the catalytic activity of natural enzymes, and are attracting a surge of research, especially in the field of biomedical research. In this review, the typical preparation strategies, catalytic mechanisms, advances and perspectives of Mn-based nanozymes for biomedical applications are systematically summarized. The application of Mn-based nanozymes in tumor therapy and sensing detection, together with an overview of their mechanism of action is highlighted. Finally, the prospective directions of Mn-based nanozymes from five perspectives: innovation, activity enhancement, selectivity, biocompatibility, and application broadening are discussed.

The tumor microenvironment (TME) is a complex and variable region characterized by hypoxia, low pH, high redox status, overexpression of enzymes, and high‐adenosine triphosphate concentrations. In recent years, with the continuous in‐depth study of nanomaterials, more and more TME‐specific response nanomaterials are used for tumor treatment. However, the complexity of the TME causes different types of responses with various strategies and mechanisms of action. Aiming to systematically demonstrate the recent advances in research on TME‐responsive nanomaterials, this work summarizes the characteristics of TME and outlines the strategies of different TME responses. Representative reaction types are illustrated and their merits and demerits are analyzed. Finally, forward‐looking views on TME‐response strategies for nanomaterials are presented. It is envisaged that such emerging strategies for the treatment of cancer are expected to exhibit dramatic trans‐clinical capabilities, demonstrating the extensive potential for the diagnosis and therapy of cancer.

MXenes family are novel two-dimensional (2D) materials that have been widely used in many fields such as cancer therapy, imaging, sensing, and electrochemistry due to their excellent photothermal and loading properties. Herein, A Ti 3 C 2 nanosheets (MXene) as a carrier for insecticide was reported. Nanocomposites were formulated by adsorbing the most widely used insecticidal substance, avermectin, onto MXene (MXene@AV). It takes full advantage of the loading and photothermal capabilities of MXene and the broad-spectrum insecticidal properties of avermectin to provide a more efficient and environmentally friendly alternative. The results show that MXene@AV exhibits excellent stability and photothermal capability, with a photothermal conversion efficiency as high as 39.84 %. The combination of photothermal contact killing and poisoning enables it to show strong lethality and sustained efficacy against the common pest Spodoptera frugiperda. Therefore, MXene@AV, an insecticide with MXene as a carrier, has the potential to be applied to agricultural pest control.