Herein, we reported the first versatile and expeditious protocol for the diversity-oriented synthesis (DOS) of fluoroalkylated amines via the photoinduced palladium-catalyzed cross coupling of 1,3-dienes, amines and fluoroalkyl iodides, which...

Herein we report the first versatile and expeditious method for the site-selective C−H fluoromethylation of aryl iodides via Pd/norbornene cooperative catalysis, which could work as a robust toolbox for the diversity-oriented synthesis (DOS) of fluoromethylated arenes. This methodology features the use of the low-cost industrial raw material CH 2 IF as the fluoromethyl source, an excellent functional group tolerance, and a broad ipso termination scope and can be expanded to the late-stage modification of biorelevant molecules.

We report a TEMPO‐mediated oxidative copper‐catalyzed synthesis of N‐(fluoroalkyl)imidazolones via the radical addition of imidazoles with iodofluoroacetate. A possible key intermediate involving TEMPO was observed by ESI‐MS. We also found that aerobic oxidation conditions were effective for the transformation in the presence of a copper catalyst, enabling access to a number of N‐(fluoroalkyl)imidazolones in moderate to good yields.