Liquid crystalpolymer (LCP) materials are considered to be promising substrates for RF-applications. In this work, the high frequency characteristics o LCP were investigated using a microstrip ring resonator.The purpose is to verify the possibility ofthe application of the material in RFpackaging. The metallization ofLCP was studiedfor the purpose ofboardfabrication. The adhesions between deposited copper and LCP layer were also measured by the shear-off-method. The standardplanarfabrication techniques were employed to complete the LCP based substrate and a multi-stagedfabricationflowfor LCP substrate has been optimized. Furthermore, flip chip (FC) bonding was carried out to bond a daisy chain chip onto the LCP substrate by using anisotropic conductive films (ACF), and thefunctionality was tested by thefour point resistance measurements. The results indicate that LCP has a dielectric constant ofabout 3 and a loss tangent ofabout 3.5x]0-3 in thefrequency range between 2 and 35 GHz. Flip-Chip bonding ofACA joint on LCP substrate shows an resistance ofabout 0. 7 Ohm. Finally, embedded technique ofactive devices into the LCP substrate has been demonstrated. IntroductionFuture electronic packaging requires better materials to handle extremely high frequency, low cost, 3D packaging and large thermal dissipation capacities [1]. Although System on a Chip (SOC) solution may work for specific application areas, System on Package (SOP) is generally considered as the best, cost effective system level package solution [2][3].With radio frequency (RF) systems' operating frequencies continuing to rise, system reliability becomes increasingly reliant on hermetic or near hermetic packaging materials [4]. Earlier, Teflon and ceramics based materials were used for the RF applications. But both of the materials were expensive. LCP has been identified as a good candidate for high frequency packaging materials [5][6]. The advantages of using LCP substrate for RF functionalities are [7-10]: high rigidity and strength, high heat resistance, low moisture absorption, adjustable CTE, near-hermeticity, high frequency properties, environmental friendliness and relatively low cost.The purpose of this paper is to present a summary of the research work carried out so far. Section 2 introduces the high frequency characteristics of LCP investigated using a microstrip ring resonator. This is to verify the possibility of the application of the material in RF packaging. Section 3 summaries the metallization of

Objectives Genetic factors play an important role in the etiology of schizophrenia (SZ). Catenin Delta 2 (CTNND2) is one of the genes regulating neuronal development in the brain. It is unclear whether CTNND2 is involved in SZ. With the hypothesis that CTNND2 may be a risk gene for SZ, we performed a case-control association analysis to investigate if CTNND2 gene single nucleotide polymorphisms (SNPs) are implicated in SZ in a Han Chinese northern population. Materials and Methods We recruited subjects from 2010 to 2022 from the Han population of northern Henan and divided them into two case-control samples, including a discovery sample (SZ = 528 and control = 528) and replication sample (SZ = 2458 and control = 6914). Twenty-one SNPs were genotyped on the Illumina BeadStation 500G platform using GoldenGate technology and analyzed by PLINK. Positive and Negative Syndrome Scale (PANSS) was used to assess clinical symptoms. Results Rs16901943, rs7733427, and rs2168878 SNPs were associated with SZ (Chi2 = 7.484, 11.576, and 5.391, respectively, df = 1; p = 0.006, 0.00067, and 0.02, respectively) in two samples. Rs10058868 was associated with SZ in male patients in the discovery sample (Chi2 = 6.264, df = 1, p = .044). Only rs7733427 survived Bonferroni correction. Linkage disequilibrium block three haplotypes were associated with SZ in the discovery and total sample. PANSS analysis of the four SNPs implicated rs10058868 and rs2168878 with symptoms of depression and excitement, respectively, in the SZ patients. Conclusion Four SNPs were identified as being correlated with SZ. The CTNND2 gene may be involved in susceptibility to SZ.

This paper takes Sanzhao Depression in Songliao Basin as the research target. Fuyu oil layer is in the 4th member of Quantou formation, Lower Cretaceous. The target layer in research area is mainly a set of shallow-water delta deposition, experienced the sedimentary evolution process from Delta plain to Delta front, reflect the water level changed from deep to shallow and back to deep. Because of the distributary channel frequently swing, single sand body thin thickness, study of micro facies must be carried out to guide further petroleum development. In the case of lack of core data, this study take advantage of seismic and logging data to analysis the micro facies of each reservoir group and sedimentary evolution of Fuyu oil layer. This paper proposes: 1. FⅢ, F Ⅱ, FⅠ3 and FⅠ2 sub-layer of Fuyu oil layer in research area is mainly Delta plain deposition; FⅠ 1 sub-layer is mainly Delta front deposition. 2. During the sedimentary period of FⅢ, FⅡ and FⅠ 3 sub-layer, the climate changed from humid to dry, sediment supply gradually increased; During the sedimentary period of FⅠ2 and FⅠ1 sub-layer, the climate changed from dry to humid, sediment supply gradually decreased.