Hoya longlingensis (E.F. Huang) and H. sichuanensis E.F. Huang are two new species of Apocynaceae from Southwestern China that are described in this study. Morphologically, the two species resemble H. tamdaoensis Rodda & T.B. Tran and H. lyi H. Lév., respectively. However, H. longlingensis differs from H. tamdaoensis by its elliptic leaves, mid-vein of leaf blades raised adaxially and depressed abaxially, lateral veins 2–4-paired, corolla yellow-green, outer angles of corona convex and spreading outside obviously. While H. sichuanensis differs from H. lyi by its obovate leaves, leaf apex rounded and base cuneate, petioles 1–3.5 cm long and ca. 3 mm in diameter, calyx lobes triangular, and corona whitish.

Rationale: Esophageal stenosis after chemotherapy in breast cancer patients is rare. Distinguishing esophageal stenosis from esophageal metastasis caused by breast cancer is important. Patient concerns and diagnosis:A 62-year-old woman diagnosed with advanced breast cancer and no distant metastases gradually developed skin changes, oral ulcers and mucosal injures after four cycles of chemotherapy. Dysphagia was the most severe symptom that greatly affected the patient's quality of life. Ultimately, esophageal stenosis and ulceration were confirmed by serial radiological examinations and endoscopic biopsy.Interventions: Due to difficulties in eating orally, the patient was initially placed on a nasogastric tube in order to improve her nutritional status. Simultaneously, she was administered powerful proton pump inhibitors. She underwent modified radical mastectomy for breast cancer after her nutritional status improved. However, the patient was still suffering from severe dysphagia after more than 4 months of follow-up. Subsequently, she underwent removable esophageal stent implantation after after unsuccessful attempts to dilate her esophagus.Outcomes: The dysphagia symptoms were immediately alleviated to a certain degree, and the dilated cavity of the upper esophagus showed slight retraction.Lessons: Esophageal stenosis is very infrequent in patients with breast cancer after chemotherapy. It needs to be. distinguished from esophageal metastasis caused by breast cancer. Esophageal stent implantation may provide benefits in terms of both symptom control and survival in patients with severe esophageal structures.

Background: Although a variety of research have significant protective action on the cardiovascular system when use of SGLT2 inhibitor, it is still unclear how can improve ventricular remodeling and fundamentally Reduce the mortality of cardiovascular. The purpose of this meta-analysis is to explore the efficacy of sodium glucose cotransporter type 2 (SGLT-2) inhibitors in improving left ventricular (LV) remodeling in patients with type 2 diabetes (T2DM).Methods: We searched articles published before September 30, 2020, regardless of language, in 4 electronic databases: PubMed, EMBASE, Cochrane Library and Web of Science. We included randomized controlled trials in this meta-analysis. The differences in the mean changes in left ventricular echocardiographic parameters between the treatment group and control group were evaluated.Results: Combined outcome indicators showed that SGLT2 inhibitors, LAVI (WMD＝-6.29，95％CI（-10，-2.58），P＜0.001) , E/e'（WMD＝-2.15，95％CI（-4.08，-0.21），P=0.003） , LVEF(WMD＝3.67，95％CI （0.59，6.75），P=0.02) , LVEDV( WMD＝-1.99，95％CI （-26.49，-22.50），P=0.87), LVESV(WMD＝-8.36，95％CI （-17.36，-0.65），P=0.07). Conclusions: SGLT2 inhibitors had a favorable effect on left ventricular systolic and diastolic function in patients with T2DM.

p<0.001), increasing age (HR:1.036/yr, p<0.001), use of anticoagulant therapy (HR:2.24, p¼0.007), more extensive surgery (HR:1.49, p¼0.012), and pre-operative chemotherapy (HR:1.53, p¼0.019) were significant for OS. The rates of MACE and all cardiac toxicities were 7.4% and 14.8%, respectively. No heart dosimetric variables predicted for MACE or all cardiac toxicity. Conclusion: Heart dose, as well as age, use of anticoagulants, presurgical chemotherapy, and the extent of surgery are predictive of worse OS in patients with NSCLC undergoing PORT. Heart V8 is the most significant dosimetric factor associated with OS. Despite the strong correlation between heart dose and OS, heart dose did not predict for cardiac events. This may indicate that the association between OS and heart dose cannot be explained fully by radiation-induced cardiac toxicities in NSCLC patients undergoing PORT.

Although the pathogenesis of type 1 diabetes mellitus (T1D) and acute myocardial infarction (AMI) remains unclear. We investigated the key genes and signaling pathways common to T1D and AMI. First, we screened differentially expressed genes (DEGs) co-expressed by T1D and AMI through gene expression synthesis (GEO) database and text mining. David database was used for enrichment and functional analysis of selected genes. The interaction between proteins (PPI) was created using STRING and Cytoscape software. MCODE is used for module analysis of PPI network. A total of 74 human genes that met the criteria were found in T1D and AMI. The first 10 central genes include STAT3, ITGAM, MMP9, ERBB2, MAPK3, FOS, MYD88, MAPK1, TFRC and TNFRSF1A.The establishment of the aforementioned key genes might serve as novel biomarkers for precision diagnosis and providing medical treatment for the occurrence of AMI in T1D patients in the future.