Purpose: Children and adolescents with cerebral palsy suffered from spastic pain that affected their quality of life. The purpose of this study was to examine the relationship between the spasticity-related pain and the quality of life about the children with cerebral palsy with spasticity-related pain in China. Methods:This was a prospective, observational, one-arm multicentre study. 137 cerebral palsy children with SRP and their parents/caregivers were recruited from three sites in China. The children and their parents/caregivers completed the Questionnaire on Pain Caused by Spasticity and PedsQL TM 4 scale.Results: 137 children with their parents/caregivers were eligible for participation in the study, and all completed the relevant investigation. According to the result of the children-report PedsQL, the total scale scores in the V2/V3 about the different age groups (5-7years old ,8-12 years old, 13-16 years old ) had no statistic significance((P > 0.05). After 3 weeks, the change compared to first time survey result was not significant (p>0.05). The total scores and each domain of PedsQL in the CP with SRP was lower than the normal group (P<0.05). On the whole, the associations between the child and parent proxy-report QPS total scores and each domain scores of PedsQL were moderate to high. The PedsQL total scores relationship to the QPS item score was moderate. Conclusion:The quality of life in the CP patients with SRP was worse than normal people and it was a steady long-term stage. The correlation between the spasticity-related pain and the quality of life was moderate to high and negative and the result from the parent proxy-report was more evident.