In this era of developed network communication, this paper analyzes the development prospect of industrial economy based on mobile information systems. Firstly, this paper compares and analyzes the relationship between the information industry and industrial economics, constructs the framework diagram between them, then establishes the VAR model to simulate the industrial economy, statistically compares the industrial economies from 2005 to 2016, and finally uses the impulse response function to correct and calculate the data results. This paper deeply analyzes the industrial economy based on mobile information, compares enterprises and small assets, studies the evolution and development law of traditional industries based on mobile information, summarizes the impact of “modular” manufacturing on the production organization of information companies, and reveals the “virtual vertical integration” of information industry manufacturing enterprises. The data show that most of the industrial economy in the first 10 years has a downward trend, with a small increase, but it is not obvious. Finally, it is concluded that the industrial economy will show a downward trend in recent years, and the annual downward trend is about 5%.