Titanium oxide films were synthesized by ionbeam-enhanced deposition. The films were prepared by depositing titanium atoms and simultaneously bombarding them with Xe+ ions at an energy of 40 keV in an O2 environment. An in vivo investigation, which entailed implanting low-temperature isotropic pyrolytic carbon (LTI carbon) cylinders, widely used to fabricate artificial heart valves, and titanium-oxide-coated LTI carbon cylinders with diameters of 5 mm and thicknesses of 0.5 mm into the ventral aorta of dogs for 14 days, showed that the amount of thrombus on the titanium-oxide-coated LTI carbon was much less than that formed on the surface of LTI carbon alone. Scanning electron microscopy (SEM) was used to observe the morphology of thrombus. On the titanium oxide films no platelet aggregation was found, almost no red blood cells were damaged, and almost no fibrin was found on the surface. However, all three characteristics were found on the surface of LTI carbon alone, proving that the blood compatibility of titanium oxide films is better than that of LTI carbon and titanium-oxide-coated LTI carbon.

To study the relaxation mechanisms of neferine (Nef) on the corpus cavernosum smooth muscle (CCSM), the CCSM cells from New Zealand White rabbits were cultured in vitro. [Ca(2+)](i) was measured by fluorescence ion digital imaging system (FIDIS), using Fluo-2/AM as a Ca(2+)-sensitive fluorescent indicator. Nef (0.1, 1 and 10 micromol l(-1)) had no effect on the resting [Ca(2+)](i) (P > 0.05). In the presence of extracellular Ca(2+) (2.5 mmol l(-1)), Nef (0.1, 1 and 10 micromol l(-1)) inhibited [Ca(2+)](i) elevation induced by high K(+) and phenylephrine (PE) in a concentration-dependent manner (P < 0.05). In calcium free solution containing egtaic acid (EGTA), Nef (0.1 micromol l(-1)) had no inhibitory effects on [Ca(2+)](i) elevation induced by PE (P > 0.05). However, Nef (1 and 10 micromol l(-1)) inhibited [Ca(2+)](i) elevation induced by PE (P < 0.05). These data suggest that Nef inhibited [Ca(2+)](i) in CCSM cells via blocking voltage-dependent Ca(2+) channel, alpha(1)-adrenoceptor-operated Ca(2+) channel and Ca(2+) release from intracellular Ca(2+) pool. This inhibitory action on [Ca(2+)](i) might be one of the relaxation mechanisms of Nef on the CCSM.

Agarwood is a highly valuable fragrant wood of Aquilaria spp. (Thymelaeaceae) which has been widely utilized in traditional medicine, religious rites, and cultural activities. This study summarizes a review on the identification of Aquilaria cultivars, volatile and non-volatile phytochemicals, pharmacological uses, and agarwood grading system to determine its quality, and different agarwood induction methods. Due to the highly demanding and depleted natural resources, the research on agarwood is still insufficient, and it has broad research and development prospects in many industries. However, due to the significant scientific nature of agarwood application, developing high-quality products and drugs from agarwood have become highly important, while no one has discussed in detail the phytochemicals uses and provided a summary until now. The main phytochemicals of agarwood include terpenoids, dominated by sesquiterpenes. For centuries, terpenoids have been used in traditional Chinese medicine and have been shown to possess various pharmacological properties, including bacteriostatic, antibacterial, sedation, analgesia, anti-inflammation, anti-asthmatic, hypoglycemic, antidepressant, and many others. Alongside biological activity screening, phytochemical advances and pharmacological research have also made certain progress. Therefore, this review discusses the research progress of agarwood in recent years and provides a reference basis for further study of Aquilaria plants and agarwood.

Purpose A common pipeline of apparel design and simulation is adjusting 2D apparel patterns, putting them onto a virtual human model and performing 3D physically based simulation. However, manually adjusting 2D apparel patterns and performing simulations require repetitive adjustments and trials in order to achieve satisfactory results. To support future made-to-fit apparel design and manufacturing, efficient tools for fast custom design purposes are desired. The purpose of this paper is to propose a method to automatically adjust 2D apparel patterns and rapidly generate acustom apparel style for a given human model. Design/methodology/approach The authors first pre-define a set of constraints using feature points, feature lines and ease allowance for existing apparels and human models. The authors formulate the apparel fitting to a human model, as a process of optimization using these predefined constraints. Then, the authors iteratively solve the problem by minimizing the total fitting metric. Findings The authors observed that through reusing existing apparel styles, the process of designing apparels can be greatly simplified. The authors used a new fitting function to measure the geometric fitting of corresponding feature points/lines between apparels and a human model. Then, the optimized 2D patterns are automatically obtained by minimizing the matching function. The authors’ experiments show that the authors’ approach can increase the reusability of existing apparel styles and improve apparel design efficiency. Research limitations/implications There are some limitations. First, in order to achieve interactive performance, the authors’ current 3D simulation does not detect collision within or between adjacent apparel surfaces. Second, the authors’ did not consider multiple layer apparels. It is non-trivial to define ease allowance between multiple layers. Originality/value The authors use a set of constraints such as ease allowance, feature points, feature lines, etc. for existing apparels and human models. The authors define a few new fitting functions using these pre-specified constraints. During physics-driven simulation, the authors iteratively minimize these fitting functions.

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