It is known that some active galactic nuclei (AGNs) transit from Type 1 to Type 2 or vice versa. There are two explanations for the so-called changing-look AGNs: one is the dramatic change of the obscuration along the line of sight, and the other is the variation of accretion rate. In this Letter, we report the detection of large amplitude variations in the mid-infrared luminosity during the transitions in 10 changing-look AGNs using the Wide-field Infrared Survey Explorer (WISE) and newly released Near-Earth Object WISE Reactivation data. The mid-infrared light curves of 10 objects echo the variability in the optical band with a time lag expected for dust reprocessing. The large variability amplitude is inconsistent with the scenario of varying obscuration, rather it supports the scheme of dramatic change in the accretion rate.

g-Aminobutyric acid (GABA) transporter subtype 1 (GAT1), which transports extracellular GABA into presynaptic neurons, plays an important regulatory role in the function of GABAergic systems. However, the contributions of the GAT1 in regulating mental status are not fully understood. In this paper, we observed the behavioral alterations of GAT1 knockout (GAT1 À/À ) mice using several depressionand anxiety-related models (eg, the forced-swimming test and the tail-suspension test for testing depression-related behaviors; the openfield test, the dark-light exploration test, the emergence test, and the elevated plus maze (EPM) test for anxiety-related behaviors). Here we found that GAT1 À/À mice showed a lower level of depression-and anxiety-like behaviors in comparison to wild-type mice. Furthermore, GAT1 À/À mice exhibited measurable insensitivity to selected antidepressants and anxiolytics such as fluoxetine, amitriptyline, buspirone, diazepam, and tiagabine in the tail-suspension test and/or the EPM test. Moreover, the basal level of corticosterone was found to be significantly lower in GAT1 À/À mice. These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice.

Optical time-domain astronomy has grown rapidly in the past decade, but the dynamic infrared sky is rarely explored. Aiming to construct a sample of mid-infrared outbursts in nearby galaxies (MIRONG), we have conducted a systematical search of low-redshift (z < 0.35) Sloan Digital Sky Survey spectroscopic galaxies that have experienced recent mid-infrared (MIR) flares using their Wide-field Infrared Survey Explorer (WISE) light curves. A total of 137 galaxies have been selected by requiring a brightening amplitude of 0.5 mag in at least one WISE band with respect to their quiescent phases. Only a small fraction (10.9%) has corresponding optical flares. Except for the four supernovae (SNe) in our sample, the MIR luminosities of the remaining sources (L 4.6 μm > 10 42 erg s −1) are markedly brighter than known SNe, and their physical locations are very close to the galactic center (median <0 1). Only four galaxies are radio-loud, indicating that synchrotron radiation from relativistic jets could contribute to MIR variability. We propose that these MIR outbursts are dominated by the dust echoes of transient accretion onto supermassive black holes, such as tidal disruption events (TDEs) and turn-on (changinglook) active galactic nuclei. Moreover, the inferred peak MIR luminosity function is generally consistent with the X-ray and optical TDEs at the high end, albeit with large uncertainties. Our results suggest that a large population of transients has been overlooked by optical surveys, probably due to dust obscuration or intrinsically optical weakness. Thus, a search in the infrared band is crucial for us to obtain a panoramic picture of nuclear outburst. The multiwavelength follow-up observations of the MIRONG sample are in progress and will be presented in a series of subsequent papers. Unified Astronomy Thesaurus concepts: Time domain astronomy (2109); Tidal disruption (1696); Active galactic nuclei (16); Infrared astronomy (786)