Small hole leakage of pipes caused by erosion and perforation is the major form leading to the leakage. The leakage rate is an important premise and foundation for consequence computation and risk evaluation. Those published papers fail to systematically study impacts of initial pressures and leakage sizes of a pipe on the leakage rate. More numerical simulation results are not verified by experimental test. This paper applies numerical simulation technology to establish the model of small hole leakage in pipes, designs and processes different leakage modules to simulate different leakage scenes, and then experimentally validates the model correctness. On this basis, this paper studies impacts of initial pressures and leakage sizes on leakage rates and obtains fluid dynamic characteristics around the leakage hole, including velocity distribution and pressure distribution. However, in actual engineering, the position of leakage hole could not be predicted and changed in general. Therefore, this paper further studies impacts of leakage hole positions on the pipe leakage rate. In this way, this research is refined and could provide a theoretical basis for emergency rescue and accident survey of pipe leakage accidents.