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Injection molding of wax patterns faces increasing demands for production rate. Proper thermal management of the injection molding tooling is capable of improving the production rate. Precise temperature control is a key to shorten the cooling time using the conformal cooling channels which are conformal to the molding cavity. However, the service life of the injection molding tooling with cooling channels will reduce significantly because the structural strength will reduce obviously. In this study, the feasibility of applying the increase in the mold thickness to maintain the structural strength of the injection molding tooling with cooling channels was verified through simulation and experiments conducted. It was found that the average variation between the results of simulation and the experiment is about 24.9%. The approximately amount of the increase in the thickness required for different diameters of cooling channels can be determined according to the trend equation of y=1.3429x-2.3429. The results can provide a reference for the conformal cooling channel design.