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Solvothermal reactions of CuI with 4-cyanopyridine (4-cypy) or 4,4 0 -bipyridine (4,4 0 -bipy) and alcohols (methanol, ethanol, propanol, isopropanol) in the presence of I 2 and a trace amount of water in acetonitrile gave rise to a family of multi-dimensional iodocuprate complexes of 4-cyanopyridinium and 5). The resulting 4-cyanopyridinium and viologen cations were generated in situ via the cleavage of the C-O bond of alcohols followed by alkylation of 4-cypy or 4,4 0 -bipy. X-ray analysis revealed that compound 1 consists of a unique three-dimensional anionic [Cu 4 I 6 ] n 2nÀ framework while compounds 2-5 contain one-dimensional anionic [Cu 2 I 4 ] n 2nÀ chains that are enclosed into different cationic channels formed by either 4-cyanopyridinium or N,N 0 -dialkyl-4,4 0 -bipyridinium. The dielectric properties of 1-5 were investigated. Experimental Materials and physical measurementsAll starting materials were purchased from commercial sources and used without further purification. Solvents were purchased as reagent grade and distilled prior to use. The elemental analyses for C, H, and N were performed on a Carlo-Erba CHNO-S

Carbohydrate antigen 19-9 (CA19-9) is an important biomarker for the early diagnosis and clinical monitoring of pancreatic cancer. Reliable, simple, and accurate methods for the detection of CA19-9 are still urgently needed. In this study, polythionine-Au composites (AuNPs@ PThi) were designed and prepared through one-pot reaction using HAuCl 4 as the co-oxidant and raw material in thionine solution containing FeCl 3 as the oxidant. AuNPs@PThi-immobilized glassy carbon electrode was used as a sensitive redox probe for electrochemical interface. AuNPs@PThi not only favored the amplification of electrochemical signals but also facilitated excellent environmental friendliness for bioassay. Maximizing the electrochemical properties of AuNPs@PThi, an effective label-free electrochemical immunoassay for the ultrasensitive and reliable detection of CA19-9 was developed. Under optimal conditions, the linear range of the proposed immunosensor was estimated to range from 6.5 to 520 U/mL, with a detection limit of 0.26 U/mL at a signal-to-noise ratio of 3. The prepared immunosensor for CA19-9 detection showed high sensitivity, stability, and reproducibility. Furthermore, the fabricated immunosensor based on AuNPs@PThi can effectively detect and distinguish clinical serum samples of pancreatic cancer and normal control with accuracy and convenience.

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