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This study proposes to develop new knowledge about how to configure digital information for pandemic rapid response, which can use blockchain and digital-driven approaches to facilitate analyses and develop a total solution. Developing and using the rich data implied by dynamic digital twins and blockchain is relevant to manage both patients and medical resources (e.g., doctors/nurses, PPE, beds and ventilators etc.) at the COVID-19 and post COVID period. This paper learns from the experiences of resources deployment/redeployment and pandemic response from UK Hospitals to explore the blockchain solutions for preparing healthcare systems ready for both efficient operation daily and in pandemic thorough (1) Lu, Xie, Chen, Ye, Fang, Meng, Pitt and Lin information integration of patient (privacy protected) flow and medical resource flow from healthcare and medical records; (2) optimizing the deployment of such resources based on hospitals, regions and local pandemic levels switching from normal to the outbreak. The main idea is to develop the novel framework for creating an inter-hospital resilient network for pandemic response based on blockchain and dynamic digital twin, which will set up innovative ways to best care for patients, protect NHS staff, and support government scientific decisions to beat COVID-19 now and manage the crisis in the future.