Brown-Sequard syndrome (BSS) is most commonly seen in patients with spinal trauma and extramedullary spinal neoplasm. Pure BSS caused by cervical disc herniation is extremely rare. Operative treatment is generally recommended those patients with BSS to improve neurological function. Here, we report a rare case of spontaneous healing of BSS caused by cervical disc herniation. Two years follow-up showed complete disappearance of symptoms without recurrence. To our knowledge, no similar cases have been reported before. Therefore, for appropriate patients, conservative treatment can be considered for a few months before deciding on surgical treatment.