Background Human mesenchymal stromal cells (MSCs) have been widely advocated to clinical use. Human skin dermis-derived fibroblasts shared similar cellular morphology and biological characteristics to MSCs, while it still keeps elusive whether fibroblasts are functionally equivalent to MSCs for therapeutic use. Methods We isolated various fibroblasts derived from human foreskins (HFFs) and human double-fold eyelids (HDF) and MSCs derived from human umbilical cords (UC-MSCs), and then comprehensively investigated their similarities and differences in morphology, surface markers, immunoregulation, multilineage differentiation, transcriptome sequencing, and metabolomics, and therapeutic efficacies in treating 2,4,6-Trinitrobenzenesulfonic acid (TNBS) induced colitis and carbontetrachloride (CCL4) induced liver fibrosis. Results Fibroblasts and UC-MSCs shared similar surface markers, strong multilineage differentiation capacity, ability of inhibiting Th1/Th17 differentiation and promoting Treg differentiation in vitro, great similarities in mRNA expression profile and metabolites, and nearly equivalent therapeutic efficacy on TNBS-induced colitis and CCL4-induced hepatic fibrosis. Conclusion Human skin dermis-derived fibroblasts were a kind of functional MSCs with functionally equivalent therapeutic efficacy in treating specific complications, indicating fibroblasts potentially had the same lineage hierarchy of origin as MSCs and had a remarkable potential as an alternative to MSCs in the treatment of a variety of diseases.

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With the purpose of investigating the effects of geometry parameters of CFJ (Coflow jet) device on the aerodynamic characteristics of the supercritical bacj airfoil used by a STOL transport, we have carried out a computational analysis of CFJ airfoil with different values of injection slot size and location under the low-speed condition. The results show that the lift coefficient decreases gradually with decreasing stall angle, when the injection slot size is increased. When α=8°, with increasing injection slot size, the velocity of blowing jet decreases with decreasing power consumption and increasing aerodynamic effectiveness. Further, with the injection slot shifted towards the downstream direction, the α value corresponding to the maximum effective lift-drag-ratio increases with increasing maximum lift coefficient.

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