Background: Metastasis of renal cell carcinoma most commonly occurs in the lungs, lymph nodes, bones, liver, and brain. It is rare for CCRCC to metastasize to the sigmoid colon after radical nephrectomy, which often signifies systemic metastasis and poor prognosis. Case Presentation: A 65-year-old woman was hospitalized for bloody stools, and she had a radical nephrectomy eight years ago after being diagnosed with CCRCC. The preoperative colonoscopic biopsy failed to clarify the nature of the mass, and the imaging examination suggested that the mass may be malignant. Following surgery to remove the mass, it was diagnosed as sigmoid metastatic CCRCC according to histopathology and immunohistochemistry. At present, she was in good health, and no clinical or radiological evidence of metastasis was found in her 11-month follow-up after surgery. Conclusion: Metastasis may take a long time to appear after radical nephrectomy, so it is essential to actively follow up and review patients who have undergone renal cancer surgery, and early detection and treatment of metastases remain crucial.
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