Background Streptococcus suis serotype 2 ( S. suis 2, SS2) is a major zoonotic pathogen that causes only sporadic cases of meningitis and sepsis in humans. Most if not all cases of Streptococcal toxic shock syndrome (STSS) that have been well-documented to date were associated with the non-SS2 group A streptococcus (GAS). However, a recent large-scale outbreak of SS2 in Sichuan Province, China, appeared to be caused by more invasive deep-tissue infection with STSS, characterized by acute high fever, vascular collapse, hypotension, shock, and multiple organ failure. Methods and FindingsWe investigated this outbreak of SS2 infections in both human and pigs, which took place from July to August, 2005, through clinical observation and laboratory experiments. Clinical and pathological characterization of the human patients revealed the hallmarks of typical STSS, which to date had only been associated with GAS infection. Retrospectively, we found that this outbreak was very similar to an earlier outbreak in Jiangsu Province, China, in 1998. We isolated and analyzed 37 bacterial strains from human specimens and eight from pig specimens of the recent outbreak, as well as three human isolates and two pig isolates from the 1998 outbreak we had kept in our laboratory. The bacterial isolates were examined using light microscopy observation, pig infection experiments, multiplex-PCR assay, as well as restriction fragment length polymorphisms (RFLP) and multiple sequence alignment analyses. Multiple lines of evidence confirmed that highly virulent strains of SS2 were the causative agents of both outbreaks.ConclusionsWe report, to our knowledge for the first time, two outbreaks of STSS caused by SS2, a non-GAS streptococcus. The 2005 outbreak was associated with 38 deaths out of 204 documented human cases; the 1998 outbreak with 14 deaths out of 25 reported human cases. Most of the fatal cases were characterized by STSS; some of them by meningitis or severe septicemia. The molecular mechanisms underlying these human STSS outbreaks in human beings remain unclear and an objective for further study.

Developments in wireless communications and wearable devices have facilitated the emergence of a network of tiny sensors embedded in, on or around human body called Wireless Body Area Network (WBAN). Over the last decade, WBAN has increasingly been playing a vital role in modern medical systems because of its potential to revolutionize healthcare delivery. The data collected by the sensors contain sensitive information and are transmitted via wireless channels. However, the openness of these channels makes WBAN vulnerable to attacks by unauthorized users. Therefore, secure authentication and data encryption schemes in WBAN are essential. The resource constraint nature of the sensors makes traditional cryptographic schemes unsuitable. Consequently, authentication schemes based on channel characteristics are proposed, which are more suitable with fewer requirements. However, existing approaches do not consider mutual authentication as well as passive/active attacks. Motivated by these limitations, we propose in this paper, a mutual authentication and data encryption scheme based on signal propagation characteristics and enhanced butterfly algorithm. To validate the effectiveness of our scheme, we conducted an extensive real-world experiment involving 5 volunteers in indoor and outdoor areas, under distinct scenarios. We further conducted security and performance analyses to validate the effectiveness of our scheme in terms of resources and its resilience to various attacks. The results of the experiments and the analyses show that our scheme could mutually identify legitimate users and protect user data against active/passive eavesdropping attacks with minimal overhead.INDEX TERMS Authentication, active attack, passive attack, signal propagation characteristic, wireless body area network (WBAN).

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With the assistance of device-to-device (D2D) communications, unmanned aerial vehicle (UAV) networks are anticipated to support widespread applications in the fifth generation (5G) and beyond wireless systems, by providing seamless coverage, flexible deployment, and high channel rate. However, the networks face significant security threats from malicious eavesdroppers due to the inherent broadcast and openness nature of wireless channels. To ensure secure communications of such networks, physical layer security is a promising technique, which utilizes the randomness and noise of wireless channels to enhance secrecy performance. This article investigates physical layer security performance via spectrum sharing in D2D-enabled UAV networks. We first present two typical network architectures where each UAV serves as either a flying base station or an aerial user equipment. Then, we propose a spectrum sharing strategy to fully exploit interference incurred by spectrum reuse for improving secrecy performance. We further conduct two case studies to evaluate the spectrum sharing strategy in these two typical network architectures, and also show secrecy performance gains compared to traditional spectrum sharing strategy. Finally, we discuss some future research directions in D2D-enabled UAV networks.