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Additive manufacturing (AM) has been developing into a revolutionary technique, in which parts are created by additive processing as opposed to the conventional subtractive manners. AM components possess the characterization of special microstructure and porosity. In this paper, a computational method is developed to investigate the mechanical property of selectively laser melted (SLM) AlSi10Mg alloy. The DREAM.3D software is utilized to generate a polycrystal model based on electron backscatter diffraction (EBSD) results. The investigated alloy shows a weak texture that the grain preferential grows along the <100> orientation. The real defect geometries are reconstructed from X-ray Computed Tomography (XCT) experimental slices and embedded into a representative volume element (RVE) model. Furthermore, a crystal plasticity (CP) model integrated fast Fourier transform method (FFT) in Düsseldorf Advanced Material Simulation Kit (DAMASK) package is implemented to simulate the mechanical response for the RVE model. The effect of porosity on tensile strength is studied, and result shows the defects degrade tensile strength.