An applicable and easy-handling Ni-catalyst can be used to promote direct arylation of α-bromonitriles with various arylboronic acids to construct α-arylnitriles under mild conditions. The methodology tolerates β-hydrogens and functional groups in the substrates.

We describe the synthesis of the N-(2-seleninatoethyl) amide of N-Boc-phenylalanine, serving here as a peptide model, and its reductive coupling reactions under mild conditions with unprotected thiouridine and glutathione. Selenosulfide products such as these comprise reversibly conjugated bio-components, and can potentially find uses as probes of biological function, such as enzyme inhibitors, delivery systems, or structural mimics.

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Novel α-Arylnitriles Synthesis via Ni-Catalyzed Cross-Coupling of α-Bromonitriles with Arylboronic Acids under Mild Conditions. -(YANG, Y.; TANG, S.; LIU, C.; ZHANG, H.; SUN, Z.; LEI*, A.; Org. Biomol. Chem. 9 (2011) 15, 5343-5345, http://dx.doi.org/10.1039/c1ob05326d ; Coll. Chem. Mol. Sci., Wuhan Univ., Wuhan, Hubei 430072, Peop. Rep. China; Eng.) -Nuesgen 48-075