The results of this meta-analysis suggest that bpMRI has high diagnostic accuracy in the detection of PCa and maintains a high detection rate for clinically relevant PCa. However, owing to high heterogeneity among the included studies, caution is needed in applying the results of the meta-analysis.

The results of this clinical study indicate that a TA-based model that includes biparametric MRI can be used for identifying high-grade prostate cancer and that specific parameters extracted from TA may be additional tools for assessing tumor aggressiveness.

Over the past 3 months, coronavirus disease 2019 (COVID-19) has emerged across China and developed into a worldwide outbreak [1]. The disease has caused varying degrees of illness. The proportion of patients with COVID-19 with non-severe illness was 84.3% on admission, and severe cases accounted for 15.7% [2]. Most of the non-severe pneumonia patients would gradually alleviate and be cured with treatment, while others would rapidly progress to severe illness, which has a poor prognosis [3, 4]. As recently reported, the cumulative risk of the composite end-point was 3.6% in all COVID-19 patients, and the cumulative risk was 20.6% for severe illness [2]. However, it is still unknown whether early identification and intervention for non-severe patients with COVID-19 could prevent progression into severe disease. According to the experience of treating other diseases, there might be a large promoting effect of treatment. In this paper, we aim to build a predictive model for identifying high-risk non-severe pneumonia patients at an early stage. 86 patients with COVID-19 and non-severe pneumonia on admission were recruited as the training cohort at Renmin Hospital of Wuhan University from 2 to 20 January, 2020, and another 62 patients were prospectively enrolled as the validation cohort from 28 January to 9 February, 2020. COVID-19 was confirmed by real-time PCR. Disease severities of COVID-19 were defined as severe and non-severe pneumonia based on the criteria of American Thoracic Society guidelines for community-acquired pneumonia [2, 5]. The exclusion criteria included: 1) degrees of severity were not available on admission or during follow-up; 2) diagnosed with severe illness at the time of admission; 3) confirmed with COVID-19 and treated at other hospitals; 4) medication was administered within 15 days before admission; 5) received oxygen support during follow-up. Patients were divided into "progressed" or "non-progressed" groups, based on whether they progressed to severe illness or not during the 14-day follow-up period. Comorbidity included diabetes, hypertension, cardiovascular and cerebrovascular diseases, COPD, malignant tumour, chronic liver disease, chronic kidney disease, tuberculosis and immunodeficiency diseases, etc. Clinical characteristics and laboratory findings were extracted from electronic medical records. Radiological features were extracted from chest computed tomography (CT) imaging using a double-blind method [6]. To evaluate the lesion size accurately, a diagnosis system for COVID-19 based on artificial intelligence (AI) was employed to measure volume ratio of pneumonia automatically by analysing CT values [7, 8]. Logistic regression was used as the classifier to build the predictive model. The discriminative performance of the predictive model was quantified by the value of the area under the receiver operating characteristic curve (AUC) in the cross-validation of the training and validation datasets. Risk index calculated with the weight of each variable in the model was used to identify...