This study mainly develops a high-efficiency single-input triple-outputs dc/dc converter (HSTDC) with a soft-switching technique for high step-up applications. In general, multiple output voltages with only one single input power source is always required for the applications of renewable energy or electric vehicles. At the high step-up operation, the proposed HSTDC has a high voltage conversion ratio to sustain the high-voltage dc bus for the utilization of dc/ac inverter. The proposed HSTDC uses a coupled inductor with lower turn ratios to achieve the high step-up voltage gain and adopts an auxiliary inductor to adjust the voltage of the auxiliary output terminal indirectly. Moreover, the utilization of voltage clamping and zero-current switching (ZCS) in the proposed HSTDC is helpful for accomplishing the goal of high-efficiency power conversion and three output voltage levels. In addition, the effectiveness of the proposed HSTDC is verified by rich experimental results.INDEX TERMS High-efficiency power conversion, single-input multiple-outputs dc/dc converter, high step-up, coupled inductor, voltage clamping, zero-current switching (ZCS).

This study mainly develops a high-efficiency isolated bidirectional DC/DC converter (HEIBDC) with a single input and multiple outputs. For the requirement of multiple output voltages with only one single input source, the proposed HEIBDC can achieve the objectives of high-efficiency power conversion and bidirectional power flow. The proposed HEIBDC can be operated at two modes, including the step-down mode and the step-up mode. At the step-down mode, the high-voltage DC bus transmits extra energy to charge the bidirectional input power source. At the step-up mode, it can transmit the energy from the input power source to the high-voltage DC bus for the possible utilization of a later DC/AC inverter, and from the auxiliary source (e.g., a battery module) to supply power for peripheral devices. The proposed HEIBDC uses a coupled inductor to increase the step-up/step-down voltage ratio and adopts an auxiliary inductor to indirectly adjust the voltage of the auxiliary output terminal. Moreover, the utilization of voltage clamping and soft switching in the proposed HEIBDC is helpful for accomplishing the goal of high-efficiency power conversion. In addition, the effectiveness of the proposed HEIBDC is verified by experimental results of a 600W prototype in practical applications. The experimental results reveal that the maximum power conversion efficiency at the step-up mode or the step-down mode is measured to exceed 96%.

Mitochondrial targeted Szeto-Schiller (SS) peptides have recently gained attention for their antioxidative stress ability; however, the functional variations between normal and cancer cells have not been determined. Here, we report the results of such experiments conducted with a newly designed class of peptide called RY4, which is based on SS peptide sequence characteristics. The RY4 peptide exhibits distinct differences in antioxidative stress response between normal and cancer cells when challenged with chemotherapeutics like the glycolytic inhibitor dichloroacetate (DCA), the platinating agent carboplatin, and the DNA damage inducer doxorubicin. Interestingly, only normal human cells were protected by the RY4 peptide and catalase (CAT) activity was significantly enhanced in normal but not tumor cells when incubated with RY4. Pull-down, coimmunoprecipitation, and LC/MS-MS proteomic analysis demonstrated that RY4 and catalase are capable of forming protein complexes. Finally, in vivo efficacy was evaluated by intraperitoneal administration of RY4 into a lung cancer xenograft model, which revealed significant myocardiocyte protection from doxorubicin-induced cardiotoxicity without diminishing doxorubicin's tumoricidal effects. Taken together, RY4 offers selective protection to normal cells from chemotherapy-induced toxicity by enhancing the activity of cellular antioxidant enzymes.

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