No abstract

Abstract.A comprehensive frequency analysis of 57 Tau, supposed only a static pulsational arrangement, is presented based on 54 nights of photometric data collected between 1981 and 1995 (althogether 232 hours). The presence of individual frequencies is confirmed by intercomparing four subsets of this data set, however, the uncertainties in data coming from the sparse nights and low signal weaken the conclusion on some results. The entire data base is then used to resolve closely spaced peaks. Twelve frequencies are indentified using this process. Further multisite observations are recommended to confirm the present frequency solution. Two periods, with a high probability of being real, are found in the low frequency domain. They are suggested to arise from binarity or g modes, as in γ Dor stars. Single unusual cycles, possessing large amplitude, or displaying asymmetry, have been localized. A coherent frequency at 29.83 c/d with variable amplitude was found. The nonstandard behaviour of the light variation indicates that nonlinear and/or nonstationary processes could be very important in the investigation of δ Scuti observations.

According to dimensionless analysis of the coalbed methane (CBM) production data of Fanzhuang block in southern Qinshui basin, the dimensionless gas production rate is calculated to quantitatively divide the CBM well production process into four stages, i.e., drainage stage, unstable gas production stage, stable gas production stage, and gas production decline stage. By the material balance method, the coal reservoir permeability change in different stages is quantitatively characterized. The characteristics and control mechanisms of change in coalbed permeability (CICP) during different production stages are concluded on five aspects, i.e., permeability trend variation, controlling mechanism, system energy, phase state compositions, and production performance. The study reveals that CICP is characterized by first decline, then recovery, and finally by increase and is controlled directly by effective stress and matrix shrinkage effects. Further, the duration and intensity of the matrix shrinkage effect are inherently controlled by adsorption and desorption features.

To investigate the auto-induction of cytochrome P450 (CYP450) by Chloroxoquinoline (CXL), a novel anticancer drug. Three experiments related to the induction of CYP450 were performed: a) In vitro use of the rat fresh hepatocytes model; b) In vivo ‘cocktail’ of CYP450 probe model; c) Pharmacokinetic (PK) study of the single and multiple doses. Some typical CYP enzyme probes and inducers were used in these experiments and were all determined by HPLC-MS/MS. The expression levels of CYP3A and CYP1A mRNA were analyzed by the real time polymerase chain reaction (RT-PCR) technique. The PK studies showed that the area under the curve (AUC0-t) and the peak concentration (Cmax) of the multiple doses were approximately 2.4-fold and 1.9-fold lower than those of the single dose, respectively (p< 0.05). Subsequent studies were conducted to study the possible induction of CXL on CYP 450. The in vivo ‘cocktail’ administration of CYP450 probe model indicated that 5 d pretreatment with CXL resulted in a mean 4.6 times increase in the metabolites/probe plasma ratios for CYP 3A and a 336% increase for CYP 1A than those of the negative control (p< 0.05). The induction effect of CXL on CYP450 was further evaluated on rat hepatocytes with four concentrations (1, 10, 50 and 100 μmol/L). Compared with the negative control, the mRNA levels of CYP 1A2 increased significantly in rat hepatocytes after treatment with 10, 50 and 100 μmol/L CXL (p< 0.05). While significant inductions of CYP 3A1 were observed in the entire treated groups. The results of the present study demonstrate enhanced and induced expression of CYP 3A and CYP 1A in response to CXL exposure in rats, suggesting that CXL is an auto-inducer of CYP 3A and CYP 1A.

Carbon dioxide miscible flooding in oil reservoirs is a general method of enhancing oil recovery, nevertheless, not all reservoirs adapt to this method. Therefore, evaluating the adaptability of carbon dioxide flooding reservoirs becomes an important problem which is urged to be solved. Through the research of carbon dioxide flooding situation and displacement mechanism, twelve factors which influenced the oil displacement effect could be obtained. Compared factors with oil recovery by means of the advanced analysis of SPSS, and chose ten factors to be the evaluating indices which could apply in cluster analysis. Through building mathematical model and clustering reservoirs, the adaptability of carbon dioxide flooding could be evaluated comprehensively. Apply this method to cluster nine typical reservoirs which have adopted carbon dioxide flooding, the results show that, this method can evaluate the adaptability of carbon dioxide flooding reservoirs, which is corresponding to the real exploitation effect.