Shape memory polymers (SMPs) are smart and adaptive materials able to recover their shape through an external stimulus. This functionality, combined with the good biocompatibility of polymers, has garnered much interest for biomedical applications. In this review, we discuss the design considerations critical to the successful integration of SMPs for use in vivo. We also highlight recent work on three classes of SMPs: shape memory polymers and blends, shape memory polymer composites, and shape memory hydrogels. These developments open the possibility of incorporating SMPs into device design, which can lead to vast technological improvements in the biomedical field.
The development of functional polymers from renewable lignin is attractive due to the depletion of fossil fuel and increasing environmental usage. A series of poly(ethylene glycol) methyl ether methacrylate (PEGMA)-grafted lignin hyperbranched copolymers were prepared by atom transfer radical polymerization (ATRP). The chemical structures, molecular characteristic and thermal properties of these copolymers were evaluated and such copolymers were prepared in a range of molecular weights from 38.7 to 65.0 kDa by adjusting the PEGMA-to-lignin weight ratio. As a result from their hyperbranch architecture, their aqueous solutions were found to form supramolecular hydrogels with a very low critical gelation concentration of 1 wt % copolymers, in the presence of α-cyclodextrin (α-CD). The rheological properties of the supramolecular assemblies were investigated and these hydrogel systems showed tunable mechanical response and excellent self-healing capability. Combined with good biocompatibility, these new types of green supramolecular hydrogels based on lignin−PEGMA/cyclodextrin inclusion are potentially useful as a smart biomaterial for biomedical application.
The incorporation of lignin–PMMA copolymers into PCL nanofibers significantly improved the mechanical properties and biocompatibility of the nanofibrous composites.
Artificial skin devices are able to mimic the flexibility and sensory perception abilities of the skin. They have thus garnered attention in the biomedical field as potential skin replacements. This Review delves into issues pertaining to these skin‐deep devices. It first elaborates on the roles that these devices have to fulfill as skin replacements, and identify strategies that are used to achieve such functionality. Following which, a comparison is done between the current state of these skin‐deep devices and that of natural skin. Finally, an outlook on artificial skin devices is presented, which discusses how complementary technologies can create skin enhancements, and what challenges face such devices.
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