A lotus‐root‐like three‐dimensional mesoporous silicon is successfully prepared by a magnesiothermic reduction method using SBA‐15 silica as both template and silicon precursor. After carbon coating via a chemical vapor deposition process, this anode material shows high reversible capacity of ∼1900 mAh g−1 and excellent rate performance even up to 15C.

The demands for green production of hydrogen peroxide have triggered extensive studies in the photocatalytic synthesis, but most photocatalysts suffer from rapid charge recombination and poor 2e − oxygen reduction reaction (ORR) selectivity. Here, a novel composite photocatalyst of cyanorich graphitic carbon nitride g-C 3 N 4 is fabricated in a facile manner by sodium chloride-assisted calcination on dicyandiamide. The obtained photocatalysts exhibit superior activity (7.01 mm h −1 under λ ≥ 420 nm, 16.05 mm h −1 under simulated sun conditions) for H 2 O 2 production and 93% selectivity for 2e − ORR, much higher than that of the state-of-the-art photocatalyst. The porous g-C 3 N 4 with Na dopants and cyano groups simultaneously optimize two limiting steps of the photocatalytic 2e − ORR: photoactivity, and selectivity. The cyano groups can adjust the band structure of g-C 3 N 4 to achieve high activity. They also serve as oxygen adsorption sites, in which local charge polarization facilitates O 2 adsorption and protonation. With the aid of Na + , the O 2 is reduced to produce more superoxide radicals as the intermediate products for H 2 O 2 synthesis. This work provides a facile approach to simultaneously tune photocatalytic activity and 2e − ORR selectivity for boosting H 2 O 2 production, and then paves the way for the practical application of g-C 3 N 4 in environmental remediation and energy supply.

The novel T-type antagonist ( S)- 5 has been prepared and evaluated in in vitro and in vivo assays for T-type calcium ion channel activity. Structural modification of the piperidine leads 1 and 2 afforded the fluorinated piperidine ( S)- 5, a potent and selective antagonist that displayed in vivo CNS efficacy without adverse cardiovascular effects.

A program currently ongoing in our laboratory envisions natural macrolide radicicol-based inhibitors targeting the molecular chaperone Hsp90. Such inhibitors can be potential anticancer agents due to their ability to induce the breakdown of a variety of oncogenic proteins. In this account, we first concern ourselves with a vastly important total synthesis of such an inhibitor. We accomplished this via a new approach, which we term the "ynolide method", directed to the synthesis of resorcinylic macrolides, including cycloproparadicicol and aigialomycin D. The key features of the syntheses involve cobalt-complexation-promoted ring-closing metathesis (RCM) to generate ynolides, followed by Diels-Alder reaction with dimedone-derived bis-siloxy dienes to elaborate the benzo system. A number of interesting analogues were synthesized using this protocol. They were evaluated for their inhibitory activity against the growth of breast cancer cell line, MCF-7. The potency of their cytotoxicity was found to be consistent with their ability to degrade the oncogenic protein, Her2. From these assays, cycloproparadicicol was identified as a most promising candidate for further development.

T-type calcium channels have been implicated in many behaviorally important neurophysiological processes, and altered channel activity has been linked to the pathophysiology of neurological disorders such as insomnia, epilepsy, Parkinson's disease, depression, schizophrenia, and pain. We have previously identified a number of potent and selective T-type channel antagonists (Barrow et al., 2007;Shipe et al., 2008;. Here we describe the properties of the antagonist, assessed in patchclamp experiments. TTA-A2 blocks T-type channels (Ca v 3.1, 3.2, 3.3) voltage dependently and with high potency (IC 50 ϳ100 nM). Stimulation at 3 Hz revealed additional use dependence of inhibition. A hyperpolarized shift of the channel availability curve and delayed channel recovery from inactivation suggest that the compound preferentially interacts with and stabilizes inactivated channels. The compound showed a ϳ300-fold selectivity for Ca v 3 channels over high-voltage activated calcium channels. Inhibitory effects on native T-type currents were confirmed in brain slice recordings from the dorsal lateral geniculate nucleus and the subthalamic nucleus. Furthermore, we demonstrate that in vivo T-type channel inhibition by TTA-A2 suppresses active wake and promotes slow-wave sleep in wild-type mice but not in mice lacking both Ca v 3.1 and Ca v 3.3, suggesting the selective effect of TTA-A2 on recurrent thalamocortical network activity. The discovery of the potent and selective T-type channel antagonist TTA-A2 has enabled us to study the in vivo effects of pharmacological T-channel inhibition on arousal in mice, and it will help to explore the validity of these channels as potential drug targets for sleep-related and other neurological diseases.