Background This study aimed to investigate the expression of serum miR-363-3p in patients with polycystic ovary syndrome (PCOS) and its predictive value for pregnancy after ovulation induction therapy. Methods The expression of serum miR-363-3p was detected by Reverse transcription quantitative polymerase chain reaction (RT-qPCR). PCOS patients were treated with ovulation induction therapy, and after the successful pregnancy was confirmed, they were followed up for 1 year in outpatient department to record the pregnancy outcomes of the patients. The Pearson correlation coefficient was used to evaluate the correlation between the expression level of miR-363-3p and biochemical indicators of PCOS patients. Logistic regression analysis was used to analyze the risk factors of pregnancy failure after ovulation induction therapy. Results The serum level of miR-363-3p in PCOS group was significantly lower than that in control group. Compared with the control group, both pregnant and non-pregnant groups had lower miR-363-3p levels, while the non-pregnant group had a greater reduction in miR-363-3p levels than the pregnant group. Low levels of miR-363-3p showed high accuracy in distinguishing pregnant and non-pregnant patients. Logistic regression analysis showed that high levels of luteinizing hormone, testosterone (T), prolactin (PRL) and low level of miR-363-3p were independent risk factors for pregnancy failure after ovulation induction in PCOS patients. Additionally, compared with pregnancy outcomes of healthy women, the incidence of premature delivery, macrosomia, and gestational diabetes in PCOS patients increased. Conclusions The expression of miR-363-3p in PCOS patients was reduced and correlated with abnormal hormone levels, suggesting that miR-363-3p may be involved in the occurrence and development of PCOS.

Ice accretion on transmission line conductor exists widely in nature, which can bring a lot of hazards. It is important and necessary to obtain characteristics of ice on different conductors for analyzing ice hazards or developing ice protection technology. A numerical method based on CFD technology for predicting ice accretion on transmission line conductor was presented in the present paper. Ice accretion on a conductor with a diameter of 26 mm was then predicted with the numerical method and an icing wind tunnel experiment. The results showed that it was acceptable to use clear cylinder as actual conductor for icing study, and the numerical results were credible. The effects of droplet diameter, liquid water content, air speed and time on icing were then investigated with the numerical method. The law that ice thickness, limit and volume varied with different icing conditions was obtained, which built a good foundation for further research.

A confluent mixer-nozzle-shaped central plug coupled design method by using the B-spline, CFD method and revised particle swarm optimization is proposed in this paper. Then, this method is used to redesign a mixed flow exhaust system with a confluent mixer, and the performance of the redesigned model is compared with the exhaust system designed by the separated method. According to the comparison results, the redesigned exhaust system has a better mass flux distribution than the original system. The difference in bypass ratio between the redesigned model and theoretical design is 2.8%. With respect to aerodynamic performance, the thrust of the redesigned exhaust system is 6.1% higher than that of the original system under the design condition, and its total pressure recovery coefficient increases to 0.995 from 0.987 of the original model. At off-design conditions, the thrust and total pressure recovery coefficient of the redesigned model increase by 4.3% and 0.6%, respectively, compared with the original model.

Objective. To study the effect of Mirena intrauterine device (IUD) on endometrial thickness, life quality score, and curative effect in patients with perimenopausal abnormal uterine bleeding. Methods. Eighty patients with perimenopausal abnormal uterine bleeding cured from January 2020 to December 2021 were enrolled as the object of study. According to random number table, the patients were classified into the study ( n = 40 ) and control ( n = 40 ) groups. The control cases were cured with medroxyprogesterone. The study cases were cured with Mirena IUD. The effective rate of clinical therapies was evaluated after 3 months of treatment. The endometrial thickness, menstrual volume score, and life quality score (WHOQOL-BREF) was measured after 1 month, 2 months, and 3 months of treatment. Results. The effective rate of patients with Mirena IUD for 3 months was higher compared to the control group ( P < 0.05 ). The endometrial thickness and menstrual volume scores of study cohort after 1 month, 2 months, and 3 months following treatment were remarkably lower than those before treatment ( P < 0.05 ) and were considerably lower than those of control cohort ( P < 0.05 ). The hemoglobin level of the studied cases after 1 month, 2 months, and 3 months after therapy was remarkably upregulated ( P < 0.05 ) and was greatly higher compared to the controlled cases ( P < 0.05 ). After 3-month treatment, the WHOQOL-BREF score of the study group was higher compared to the control group ( P < 0.05 ). Conclusion. The Mirena IUD is far more effective in the treatment of perimenopausal abnormal uterine bleeding and is helpful in reducing the thickness of the endometrium. Patients’ menstrual flow can be controlled, and anemia can be corrected; thus, patients improve their quality of life and health status and can be considered for further promotion.