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Rock fractures have a significant impact on the stability of geotechnical engineering, and grouting is currently the most commonly used reinforcement method to address this issue. To ensure the stability of grouted rock mass, it is necessary to study its deformation law and mechanical properties. In this study, theoretical analyses and laboratory experiments were conducted, and the fracture width, Weibull model and effective bearing area were introduced to improve the applicability and accuracy of the original damage constitutive model. Moreover, the constitutive model of grouted rock mass was derived by combining it with the mixing law of composite materials. The main conclusions are summarized as follows: (1) Based on macroscopic damage tensor theory, the fracture width parameter was introduced, which effectively described the variation law of macroscopic damage with fracture width to improve the accuracy of the original damage constitutive model. (2) The effective bearing area was used to optimize the original Weibull model to match the stress-strain curve of the rock mass with fractures. (3) The grouting-reinforced rock mass was considered to be a composite material, the original equivalent elastic modulus model was improved by combining macroscopic damage with the Reuss model, and the constitutive damage model of the grouted rock mass was deduced.