Osteosarcoma (OS) is one of the most common primary solid malignant tumors in orthopedics, and its main clinical treatments are surgery and chemotherapy. However, a wide surgical resection range, functional reconstruction of postoperative limbs, and chemotherapy resistance remain as challenges for patients and orthopedists. To address these problems, the discovery of new effective conservative treatments is important. Long non-coding RNAs (lncRNAs) are RNAs longer than 200 nucleotides in length that do not encode proteins. Researchers have recently found that long non-coding RNAs are closely associated with the development of OS, indicating their potentially vital role in new treatment methods for OS. This review presents new findings regarding the association of lncRNAs with OS and summarizes potential clinical applications of OS with lncRNAs, including the downregulation of oncogenic lncRNAs, upregulation of tumor suppressive lncRNAs, and lncRNAs-based treatment to improve chemotherapy resistance. We hope these potential methods will be translated into clinical applications and greatly reduce patient suffering.

The management and definitive treatment of critical-size bone defects in severe trauma, tumor resection and congenital malformation are troublesome for orthopedic surgeons and patients worldwide without recognized good treatment strategies. Researchers and clinicians are working to develop new strategies to treat these problems. This review aims to summarize the techniques used by additive manufacturing scaffolds loaded with BMP-2 to promote osteogenesis and to analyze the current status and trends in relevant clinical translation. Optimize composite scaffold design to enhance bone regeneration through printing technology, material selection, structure design and loading methods of BMP-2 to advance the clinical therapeutic bone repair field.

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Purpose: The aim of this study was to explore the correlation between the change of patella height and postoperative functional outcomes, range of motion, and patellar crepitus after total knee arthroplasty. Materials and methods: Analysis of an observational, retrospective case series was conducted on 116 patients suffering total knee arthroplasty in the Department of Orthopedics from August 2020 to September 2022. According to the mBP ratio of postoperation, the patients were divided into normal patella height, patella baja, and patella alta groups. The primary conditions, KSS, range of motion of keen, and patellar crepitus were collected from the patients in each group during follow-up. Outcome assessors were blinded to the groups during the study. Results: There was no significant difference in the knee score of KSS among the groups (P = 0.024); the patella baja group significantly differed in the range of motion compared to the normal patella group (P = 0.037); a statistically significant difference existed in the patella baja group and the normal patella group for the patellar crepitus (P < 0.001); Conclusion: In the patients who underwent the total knee arthroplasty without patella replacement, it was found that abnormal patella position had no significant influence on postoperative KSS, but patella baja seemed to reduce the postoperative range of motion, and increase the rate of patella crepitus.