Pore fluids strongly influence the seismic properties of rocks. The densities, bulk moduli, velocities, and viscosities of common pore fluids are usually oversimplified in geophysics. We use a combination of thermodynamic relationships, empirical trends, and new and published data to examine the effects of pressure, temperature, and composition on these important seismic properties of hydrocarbon gases and oils and of brines. Estimates of in-situ conditions and pore fluid composition yield more accurate values of these fluid properties than are typically assumed. Simplified expressions are developed to facilitate the use of realistic fluid properties in rock models. Pore fluids have properties that vary substantially, but systematically, with composition, pressure, and temperature. Gas and oil density and modulus, as well as oil viscosity, increase with molecular weight and pressure, and decrease with temperature. Gas viscosity has a similar behavior, except at higher temperatures and lower pressures, where the viscosity will increase slightly with increasing temperature. Large amounts of gas can go into solution in lighter oils and substantially lower the modulus and viscosity. Brine modulus, density, and viscosities increase with increasing salt content and pressure. Brine is peculiar because the modulus reaches a maximum at a temperature from 40 to 80°C. Far less gas can be absorbed by brines than by light oils. As a result, gas in solution in oils can drive their modulus so far below that of brines that seismic reflection bright spots may develop from the interface between oil saturated and brine saturated rocks.

Part one of this paper presents a method for measuring seismic velocities and transverse isotropy in rocks using a single core plug. This method saves at least two‐thirds of the time for preparing core samples and measuring velocities in transversely isotropic (TI) rocks. Using this method, we have measured velocity and anisotropy of many shale and reservoir rocks from oil and gas fields around the world. We present some of the data in this paper, which include seismic velocity and anisotropy in 17 brine‐saturated shale samples, 1 gas‐ and brine‐saturated coal sample, 8 brine‐saturated sands, 12 gas‐saturated sands, 32 gas‐saturated carbonate samples, and 25 brine‐saturated carbonate samples. The results show that clays and fine layering in sedimentary rocks are the main causes of seismic anisotropy. Very little intrinsic anisotropy exists in unfractured reservoir rocks such as sands, sandstones, and carbonates under reservoir conditions. In contrast, all shales were found seismically anisotropic: anisotropy ranges from 6% to 33% for P‐waves and from 2% to 55% for S‐waves. The magnitude of shale anisotropy seems to decrease exponentially with increasing porosity. At present, the magnitude of shale anisotropy cannot be predicted accurately from other data without laboratory measurements. This paper also presents some best practices for laboratory measurements of shale velocity and anisotropy.

Clay minerals are perhaps the most abundant materials in the earth's upper crust. As such, their elastic properties are extremely important in seismic exploration, seismic reservoir characterization, and sonic-log interpretation. Because little exists in the literature on elastic properties of clays, we have designed a method of measuring effective elastic properties of solid clays (clays without pores). In this method, clay minerals are mixed with a material with known elastic properties to make composite samples. Elastic properties of these clay minerals are then inverted from the measured elastic properties of the composite samples using the weighted Hashin-Shtrikman average.Using this method, we have measured 66 samples of 16 types of clays. In this paper, we present a comprehensive data set of elastic properties of solid clays that commonly occur in, or are related to, petroleum reservoirs. Although uncertainties (up to 10%) exist, the data set reported here is by far the most comprehensive set of elastic properties in the literature. These data can be used potentially in modeling the seismic properties of clay-bearing rocks.

During the past 50 years or so, tremendous progress has been made in studying physical properties of rocks and minerals in relation to seismic exploration and earthquake seismology. During this period, many theories have been developed and many experiments have been carried out. Some of these theories and experimental results have played important roles in advancing earth sciences and exploration technologies. This tutorial paper attempts to summarize some of these results.

Fatty acid oxidation (FAO) is crucial for cells to overcome metabolic stress by providing ATP and NADPH. However, the mechanism by which FAO is regulated in tumors remains elusive. Here we show that Nur77 is required for the metabolic adaptation of melanoma cells by protecting FAO. Glucose deprivation activates ERK2 to phosphorylate and induce Nur77 translocation to the mitochondria, where Nur77 binds to TPβ, a rate-limiting enzyme in FAO. Although TPβ activity is normally inhibited by oxidation under glucose deprivation, the Nur77-TPβ association results in Nur77 self-sacrifice to protect TPβ from oxidation. FAO is therefore able to maintain NADPH and ATP levels and prevent ROS increase and cell death. The Nur77-TPβ interaction further promotes melanoma metastasis by facilitating circulating melanoma cell survival. This study demonstrates a novel regulatory function of Nur77 with linkage of the FAO-NADPH-ROS pathway during metabolic stress, suggesting Nur77 as a potential therapeutic target in melanoma.