Magnolol and Honokiol are the primary active components that have been identified and extracted from Magnolia officinalis, and several investigations have demonstrated that they have significant pharmacological effects. Despite their therapeutic benefits for a wide range of illnesses, research on and the implementation of these compounds have been hindered by their poor water solubility and low bioavailability. Researchers are continually using chemical methods to alter their structures to make them more effective in treating and preventing diseases. Researchers are also continuously developing derivative drugs with high efficacy and few adverse effects. This article summarizes and analyzes derivatives with significant biological activities reported in recent research obtained by structural modification. The modification sites have mainly focused on the phenolic hydroxy groups, benzene rings, and diene bonds. Changes to the allyl bisphenol structure will result in unexpected benefits, including high activity, low toxicity, and good bioavailability. Furthermore, alongside earlier experimental research in our laboratory, the structure‐activity relationships of magnolol and honokiol were preliminarily summarized, providing experimental evidence for improving their development and utilization.

In the title compound, C16H11ClO6, the dihedral angle between the two benzene rings is 86.9 (3)°.

Key indicatorsSingle-crystal X-ray study T = 294 K Mean (C-C) = 0.005 Å R factor = 0.045 wR factor = 0.120 Data-to-parameter ratio = 12.4For details of how these key indicators were automatically derived from the article, see

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In the title compond C20H20O6, the benzofuran ring system is nearly planar. The crystal structure is stabilized by O—H⋯O hydrogen bonds.