Computed tomography perfusion (CTP) is a functional imaging that allows for providing capillary-level hemodynamics information of the desired tissue in clinics. In this paper, we aim to offer insight into CTP imaging which covers the basics and current state of CTP imaging, then summarize the technical applications in the CTP imaging as well as the future technological potential. At first, we focus on the fundamentals of CTP imaging including systematically summarized CTP image acquisition and hemodynamic parameter map estimation techniques. A short assessment is presented to outline the clinical applications with CTP imaging, and then a review of radiation dose effect of the CTP imaging on the different applications is presented. We present a categorized methodology review on known and potential solvable challenges of radiation dose reduction in CTP imaging. To evaluate the quality of CTP images, we list various standardized performance metrics. Moreover, we present a review on the determination of infarct and penumbra. Finally, we reveal the popularity and future trend of CTP imaging.

Computed tomography (CT) is a widely used medical imaging modality which is capable of displaying the fine details of human body. In clinics, the CT images need to highlight different desired details or structures with different filter kernels and different display windows. To achieve this goal, in this work, we proposed a deep learning based ”All-in-One” (DAIO) combined visualization strategy for high-performance disease screening in the disease screening task. Specifically, the presented DAIO method takes into consideration of both kernel conversion and display window mapping in the deep learning network. First, the sharp kernel, smooth kernel reconstructed images and lung mask are collected for network training. Then, the structure is adaptively transferred to the kernel style through local kernel conversion to make the image have higher diagnostic value. Finally, the dynamic range of the image is compressed to a limited gray level by the mapping operator based on the traditional window settings. Moreover, to promote the structure details enhancement, we introduce a weighted mean filtering loss function. In the experiment, nine of the ten full dose patients cases from the Mayo clinic dataset are utilized to train the presented DAIO method, and one patient case from the Mayo clinic dataset are used for test. Results shows that the proposed DAIO method can merge multiple kernels and multiple window settings into a single one for the disease screening.