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Background: Brain glioblastoma multiforme (GBM) is the most common primary malignant intracranial tumor. The prognosis of this disease is extremely poor. While the introduction of β-interferon (IFN-β) regimen in the treatment of gliomas has significantly improved the outcome of patients; The mechanism by which IFN-β induces increased TMZ sensitivity has not been described. Therefore, the main objective of the study was to elucidate the molecular mechanisms responsible for the beneficial effect of IFNβ in GBM.Methods: Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) GBM and GSE83300 dataset from the Gene Expression Omnibus.Univariate Cox regression analysis and lasso Cox regression model established a novel 4-gene IFN-β signature (peroxiredoxin 1, Sec61 subunit beta, X-ray repair cross-complementing 5, and Bcl-2-like protein 2) for GBM prognosis prediction. Further, GBM samples (n=50) and normal brain tissues (n=50) were then used for real-time polymerase chain reaction experiments. Gene set enrichment analysis (GSEA) was performed to further understand the underlying molecular mechanisms. Pearson correlation was applied to calculate the correlation between the long non-coding RNAs (lncRNAs) and IFN-β-associated genes.An lncRNA with a correlation coefficient |R 2 |>0.3 and P<0.05 was considered to be an IFN-β-associated lncRNA.Results: Patients in the high-risk group had significantly poorer survival than patients in the low-risk group. The signature was found to be an independent prognostic factor for GBM survival. Furthermore, GSEA revealed several significantly enriched pathways, which might help explain the underlying mechanisms. Our study identified a novel robust 4-gene IFN-β signature for GBM prognosis prediction.The signature might contain potential biomarkers for metabolic therapy and treatment response prediction for GBM patients.Conclusions: In the present study, we established a novel IFN-β-associated gene signature to predict the overall survival of GBM patients, which may help in clinical decision making for individual treatment.

Purpose The purpose of this paper is to explore the concept of information culture in Mainland China and apply the information culture framework to an organizational setting. Design/methodology/approach The foundation for the research is provided by a review of Chinese and English language literature and a case study of a university library was conducted, involving semi-structured interviews. Findings The information culture framework facilitated identification of factors not recognized in previous information culture research, including uniquely Chinese factors of egocentrism, guanxi (relationships), mianzi (face), hexie (harmony) and renqing (mutual benefit). A further finding highlighted the profound differences between archives and library institutions in China. Originality/value The paper provides the first step toward further exploring features of Chinese organizational culture which will not only influence information management practices but also highlight the issues relating to collaboration between libraries and archives in China.

Purpose The purpose of this paper is to report the results of a qualitative study exploring the conditions associated with the creation, preservation and transmission of Shuishu archives in China, and the crises today in their preservation and transmission and the reasons behind them. It also proposes activation mechanisms to shift Shuishu archives from jeopardized collective memory to preservable cultural memory. Design/methodology/approach Semi-structured interviews and ethnographic fieldwork were conducted over the course of a month in 2015. Findings The creation, preservation and transmission of Shuishu archives in the community of the Shui rely upon the community’s closed system. But this system has been broken as a result of modernization and wide use of new media in China. To preserve and transmit Shuishu archives to future generations, there needs to be mutual trust and equitable cooperation between government archives and the Shuishushi. The “cultural consciousness” of the Shui needs to be stimulated, and more members of the Shui and the whole of society need to participate in the preservation and transmission of this distinctive memory. Practical implications The study can provide a provocative example for education in preservation and LIS about community culture and archiving, and the preservation of social memory, identity and culture. The activation mechanisms seek to aid in the preservation and transmission of Shuishu archives and other similar community memory. Originality/value The study uses semi-structured interviews and ethnographic methodology to develop a rich understanding of the history and the status quo of the preservation and transmission of Shuishu archives. It redefines Shuishu archives and sheds light on the roles government archives should play in the preservation and transmission of Shuishu archives.