Background:Inflammatory Pseudo Tumor (IPT)-like Follicular Dendritic Cell (FDC) Sarcoma of the liver is a very rare disease and occurs mostly in the lymph nodes. Till now, only 19 cases were reported in the English literature. However, the coexistence of IPT-like Sarcoma and Non-Hodgkin’s Lymphoma(NHL) in the same patient has never been reported.Case presentation:We reported a case of a 47-year-old male patient who had a history of Hepatitis B virus (HBV) infection and presented with right upper abdominal discomfort. Nineteen years ago, he underwent liver resection of segment VII for Hepatic Non-Hodgkin Lymphoma (B-cell lymphoma). Serum alpha fetoprotein (AFP) level was normal. However, Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as (Hepatocellular Carcinoma) HCC or Hepatic Lymphoma preoperatively. Right hemi-hepatectomy was performed on this patient. Histological report showed features of a mixture of chronic inflammatory cells and variable amounts of spindle cells. Also, Immuno-Histo-Chemical (IHC) studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive stainings with CD21 and CD35. The patient is still disease free after a follow-up of 40 months. Conclusions:To our knowledge, this is the first report demonstrating Hepatic IPT-like FDC Sarcoma in a patient with Primary Hepatic Non-Hodgkin Lymphoma history. In regards to treatment, complete surgical resection should be performed and would acquire excellent long-term outcomes.

Background: Hepatitis B virus (HBV) may be a risk factor for cholangiocarcinoma, but it is not yet clear that the relationship between hepatitis B core antibody (HBcAb)-positive and hilar cholangiocarcinoma (hCCA). In addition, we evaluated the impact of HBcAb-positive on the safety of major hepatectomy for hCCA. Methods：A retrospective analysis was performed on the status of hepatitis B infection, liver fibrosis, surgical safety, and long-term postoperative survival of 111 patients who underwent major hepatectomy in Tongji Hospital from April 2012 to September 2019.Results: HBsAg-positive was identified in 10.6%, HBcAb-positive was found in 73.7% of the patients. A high-grade of liver fibrosis was detected in 67.9% of the patients with HBcAb-positive, which was markedly higher than that in the patients with HBcAb-negative (43.3%) (P=0.018). The incidence rates of postoperative complications and 30-day mortality were 38.7% (43/111) and 5.4% (6/111), respectively. Multivariate analysis showed that the independent risk factors for complications were HBcAb, vascular reconstruction, lymphadenectomy, HBcAb-positive correlated with a higher incidence of complications after major hepatectomy for hCCA (adjusted hazard ratio [HR] 3.984, 95%CI 1.354-11.73; P = 0.012). All the patients who died within 30-day after surgery were HBcAb-positive. However, there was no correlation between HBcAb and long-term prognosis of major hepatectomy for hCCA.Conclusions: HBcAb-positive is closely correlated with hCCA. HBcAb-positive markedly increased the incidence of postoperative complications and mortality of major hepatectomy for hCCA.

BackgroundInflammatory pseudotumor (IPT)-like follicular dendritic cell (FDC) sarcoma of the liver is very rare and mostly occurs in females. Up to now, 19 cases were reported in the English literature. Surgical resection remains the preferred method for the management of this kind of tumor. Case presentationWe reported a case of a 47-year-old male patient who had hepatitis B virus infection history and presented with up-abdominal discomfort. He underwent liver resection of segment VII for hepatic non-hodgkin lymphoma (B-cell lymphoma) 19 years ago. Serum alpha fetoprotein was normal. Imaging studies revealed a well-circumscribed, solid mass in the right hepatic lobe and was diagnosed as HCC or hepatic lymphoma. Right hemihepatectomy was performed and the patient was disease free after a follow-up of 20 months. Histological feature showed a mixture of chronic inflammatory cells and variable amounts of spindle cells. Immunohistochemical studies demonstrated that all the tumor cells showed strong nuclear in situ labeling for EBV-encoded small RNAs (EBER) and strongly positive staining with CD21 and CD35. A diagnosis of hepatic IPT-like FDC sarcoma was rendered. The coexistence of IPT-like sarcoma and non-Hodgkin’s lymphoma in same patient is extremely rare. He remains disease-free more than 40 months after surgical resection.ConclusionTo our knowledge, this is the first report to demonstrate hepatic IPT-like FDC sarcoma in a patient with primary hepatic non-hodgkin lymphoma history. Complete surgical resection should be pursued.