No abstract

To broaden the applications of magnetized water(MW) in medical science, the possible detoxicative effect of MW to anticancer drugs in vivo were studied. After being given ip with cyclophosphomide (CTX) 500 mg/ kg, cisplatin (DDP) 40 mg/kg, harringtonine (HA) 20 mg/kg, mitomycin C (MMC) 8 mg/kg, lycobetaine (Lyc) 200 mg/kg, respectively, the mice were given MW ip 0.2 ml for 7 days. The average life span was calculated for each group. After being given subacutely lower doses of anticancer drugs ( CTX 100 mg/kg, HA 3 mg/kg ) ip 3 times, the mice were given MW ip 0.2 ml for 7 days and the blood white cells were counted as routine. It was shown that the mice in MW groups after ip anticaneer drugs survived longer than those without MW. The effects of various anticancer drugs on life span were different. The white cell numbers of groups with MW were higher than that of the groups without MW. So it is possible that MW can remarkably extend the life span of mice and attenuate the leukopenia by mitigating the toxicity of anticancer drugs in vivo.

Background: New Urbanization is a major strategic decision for building socialism with Chinese characteristics, which has a profound significance for the comprehensive moves to finish building a moderately prosperous society, accelerating the process of socialist modernization, and other causes. The development of new urbanization requires the support of relevant mechanism and system, according to documents released by the State Council, promoting the innovation of urbanization system is a crucial component to the cause of new urbanization in 2015. Methods: Based on the way urbanization system is stipulated in The National New Urbanization Plan (2014)(2015)(2016)(2017)(2018)(2019)(2020), we analyze how the fund security mechanism promotes the innovation of urbanization system in Western China from the perspective of public finance and taxation. Results: Urbanization and fund security are related, public funding is important to urbanization and there exists multiple shortcomings in the process of urbanization in terms of public funding and taxation. Conclusions: Urbanization system can be promoted by improving the institution of fiscal transfer payment and local tax system.

As the investigation indexes of low-temperature viscoelastic properties of polymer-modified asphalt (PMA) are unclear at present, in this paper, the creep stiffness (S), creep rate (m), low-temperature continuous classification temperature (TC), ΔTC, m/S, relaxation time (λ), and dissipation energy ratio (Wdt/Wst) were taken as a comparison sequence. The maximum flexural tensile strain (εB) of porous asphalt mixture (PAM) in a low-temperature bending test was selected as a reference sequence. Gray relational analysis was used to investigate the PMA’s low-temperature viscoelastic properties based on a bending beam rheometer (BBR). The results show certain contradictions in investigating the low-temperature properties of PMA when only considering the low-temperature deformation capacity or the stress relaxation capacity. The modulus and relaxation capacity should be considered when selecting the investigation indexes of the low-temperature viscoelastic properties of PMA. When rheological method is used to evaluate the low-temperature of polymer modified asphalt, TC and m/S are preferred. When only S or m is contradictory, m should be preferred. ΔTC can determine whether the low-temperature performance of PMA is dominated by S or m. The result can better guide the construction of asphalt pavement in areas with low temperatures. Asphalt can be selected quickly and accurately to avoid the waste of resources.

The etiology of recurrent pregnancy loss (RPL) is complicated and effective clinical preventive measures are lacking. Identifying biomarkers for RPL has been challenging, and to date, little is known about the role of N6-methyladenosine (m6A) regulators in RPL. Expression data for m6A regulators in 29 patients with RPL and 29 healthy controls were downloaded from the Gene Expression Omnibus (GEO) database. To establish a diagnostic model for unexplained RPL, differential gene expression analysis was conducting for 36 m6A regulators using least absolute shrinkage and selection operator (LASSO) regression. Unsupervised cluster analysis was conducted on hub genes, and probable mechanisms were explored using gene set enrichment analysis (GSEA) and gene ontology (GO) analysis. Correlations between m6A-related differentially expressed genes and immune infiltration were analyzed using single-sample GSEA. A total of 18 m6A regulators showed significant differences in expression in RPL: 10 were upregulated and eight were downregulated. Fifteen m6A regulators were integrated and used to construct a diagnostic model for RPL that had good predictive efficiency and robustness in differentiating RPL from control samples, with an overall area under the curve (AUC) value of 0.994. Crosstalk was identified between 10 hub genes, miRNAs, and transcription factors (TFs). For example, YTHDF2 was targeted by mir-1-3p and interacted with embryonic development-related TFs such as FOXA1 and GATA2. YTHDF2 was also positively correlated with METTL14 (r = 0.5983, p < 0.001). Two RPL subtypes (Cluster-1 and Cluster-2) with distinct hub gene signatures were identified. GSEA and GO analysis revealed that the differentially expressed genes were mainly associated with immune processes and cell cycle signaling pathway (normalized enrichment score, NES = -1.626, p < 0.001). Immune infiltration was significantly higher in Cluster-1 than in Cluster-2 (p < 0.01). In conclusion, we demonstrated that m6A modification plays a critical role in RPL. We also developed and validated a diagnostic model for RPL prediction based on m6A regulators. Finally, we identified two distinct RPL subtypes with different biological processes and immune statuses.