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Tobacco dust represents a critical threat to the operators’ respiratory health. Even when wet scrubbers display high purification efficiencies and strong adaptability to dust, their potential applications in the tobacco industry have not been studied. In the present research, removal efficiency of wet scrubber for tobacco dust and fine dust were examined at laboratory and industrial level. Results showed that the dust removal efficiency of the wet scrubber under laboratory conditions reached a maximum value of 99.17%. In addition, the dust discharge concentration was reduced to a minimum value of 1.1 mg/m3. Our data indicated that after using the wet scrubber, large dust particles (≥10 μm) were more effectively removed than fine dust particles (≤5 μm). After the use of the wet scrubber at the industrial facility, the overall dust removal efficiency reached a value of 98.9%, and dust concentration at the discharge point was as low as 1 mg/m3. This value complies with the ultra-low discharge standard and industrial production requirements. Our study demonstrated the feasibility of using wet scrubbers in the removal of tobacco dust and provides new insights for dust suppression in the tobacco processing industry.