The inclusion complex of resveratrol (RV) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) prepared by supercritical antisolvent (SAS) process was investigated to improve its aqueous solubility. The phase solubility diagram with HP‐β‐CD was classified as AL type, and the calculated apparent complexation constant (KC) was 5,988 M−1 at 298K. Inclusion complexes were analyzed by differential scanning calorimetry (DSC), powder X‐ray diffractometry (PXRD), Fourier‐transform infrared spectroscopy (FT‐IR) and scanning electron microscopy (SEM). No endothermic and characteristic diffraction peaks corresponding to RV were observed for the inclusion complex in DSC and PXRD. FT‐IR study demonstrated the presence of intermolecular hydrogen bonds between RV and HP‐β‐CD in inclusion complex, resulting in the formation of amorphous form. Furthermore, the SAS‐processed RV/ HP‐β‐CD powders showed a significant enhancement in the solubility of RV (up to 25.13 mg/mL) in an aqueous medium. The percent dissolution of RV increased considerably and about 100% of RV was dissolved within 5–10 min. PRACTICAL APPLICATIONS In this study, the supercritical antisolvent (SAS) process was effectively utilized to prepare solid‐state inclusion complexes of resveratrol (RV) and hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD). The SAS‐processed RV/HP‐β‐CD powders showed a significant enhancement in the solubility of RV (up to 25.13 mg/mL) in an aqueous medium. The percent dissolution of RV increased considerably and about 100% of RV was dissolved within 5–10 min. This work thoroughly overcomes the high hydrophobicity and sensitivity of resveratrol to air and light, so that obviously enlarges the application in pharmaceutical, chemical, food and cosmetic industries.

Ganciclovir (GCV) is only slightly soluble in water and hence oral GCV gives low absolute bioavailability. Liquid precipitation is an effective way to prepare micro-sized drug particles. The solubility of GCV in several solvents or in aqueous solution at different pH values was determined. According to its solubility behavior, reactive precipitation was suggested as the micronization method of GCV. The mean particle diameter of micronized GCV powder was around 15~20 μm, smaller than that of raw GCV powder, and the size distribution of micronized GCV was narrower than that of raw GCV. The stirring rate, the type and addition of stabilizing agents seemed to have no significant effect on the particle size of micronized GCV. Micronized GCV showed much faster dissolution rate than raw GCV.