Background: The contextual and interactive learning research was motivated by the need to enhance the healthcare training effect of caregivers of patients with suspected COVID-19 infection during quarantine. However, there is a lack of effective approaches to integrating mobile contextual learning into interactive learning.Objectives: Therefore, this study developed a mobile augmented reality-integration contextual interactive healthcare training system, and then investigated the effects of the proposed system on anxiety, learning effects, perceived support and self-efficacies.Methods: To validate the effectiveness of the system, we conducted a quasiexperiment with a sample of 91 caregivers of patients with suspected COVID-19 infection.Results and conclusions: Results showed that the experimental group with the developed system was superior to the control group with e-pamphlet instruction in mobile devices, in terms of learning effect, perceived support, self-efficacies and reduction of anxiety during quarantine. Therefore, the mobile contextual interactive healthcare training system could be useful to improve caregivers' self-efficacies as well as their ability to care for patients in the context of COVID-19 infection prevention.Implications: This is one of the few studies of the effective approach for technologyenhanced healthcare education in the COVID-19 pandemic. Some corresponding suggestions are proposed: implementing mobile contextual interactive training activities to enhance caregivers' knowledge, skills and self-efficacies; involving social interactions to relieve caregivers' anxiety; providing professional communications and support while facing difficulties in taking care of patients with suspected COVID-19 infection.

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