A Cu-catalyzed enantioselective ring-opening/oxidative phosphorylation reaction of cyclic diaryliodonium salts and diarylphosphine oxides in the presence of TEMPO was reported. 18O-Labeled experiments showed that the reaction proceeded via oxidation, followed by C–O bond formation. Furthermore, atropisomeric phosphine oxides were prepared via a t-BuLi-mediated P-transfer reaction. Computational studies elucidated that the phosphine oxide transfer was through a concerted C–P bond formation and P–O bond-dissociation process.

The objective of the present study was to evaluate the anti-inflammatory effects ofBifidobacterium animalissubsp.lactisstrain BB12 in stimulated Caco-2 cells and to characterize the factors responsible for these anti-inflammatory effects. Characterization and purification studies indicate that BB12's anti-inflammatory factors might include a 50-kDa proteinaceous compound that is stable under a variety of heat and pH conditions.

Two convenient and practical methods for the synthesis of axially chiral biaryls bearing trifluoromethylthiol group are reported. Cu-catalyzed enantioselective ring-opening reaction of cyclic diaryliodoniums with CsSCF3 enables a direct synthesis...