Unsymmetrical dimethylhydrazine (UDMH), as a high-energy liquid propellant, is widely used in aerospace, rocket, aircraft, and other fields. However, it also has certain toxicity, fire, and explosion risks, which will cause harm to the human liver, kidney, central nervous system, blood system, etc., especially the nervous system. UDMH is easy to be adsorbed on the surface of the human body or other substances, but there is a lack of research reports on the measurement of its adsorption capacity. In this paper, based on the principle of measuring gas adsorption capacity by the volumetric method, a set of UDMH gas adsorption capacity testing devices was built. In the experiment, 304 and 316L stainless steel materials were used as the adsorbent. Under the same experimental temperature and pressure conditions, the test bottle containing the adsorbent was filled with UDMH gas of different concentrations and fully adsorbed until saturation to explore the influence of 304 stainless steel surface roughness and 304 and 316L stainless steel materials on the adsorption capacity of UDMH gas under the same experimental conditions. The experimental results show that the adsorption capacity of 304 and 316L stainless steel materials to UDMH gas increases with the increase of UDMH gas concentration in the concentration range (0~100 ppm) studied in this paper. After polishing the surface of 304 stainless steel material, compared with the unpolished 304 stainless steel material under the same conditions, the adsorption capacity after polishing is significantly smaller, indicating that the larger the surface roughness of the adsorbent, the more adsorption capacity. Under the same conditions, the adsorption capacity of UDMH gas on 304 and 316L stainless steel materials is approximately equal. The experiment also proves that the adsorption of UDMH gas on stainless steel materials conforms to monolayer adsorption within the concentration range studied in this paper.

Background: Sepsis is a life-threatening organ dysfunction caused by a maladjusted host response to infection (Sequential Organ Failure Assessment [SOFA] ≥ 2). PaCO2 is a blood gas that is commonly tested in hospitalized patients. Few studies have investigated how abnormal PaCO2 levels influence the prognosis of sepsis patients. Methods: A retrospective study was applied to data on sepsis patients extracted from the MIMIC-III public database and the results of their first PaCO2 examination after admission. The outcome measure was all-cause death within 90 days of follow-up. The patients were divided into five quintile groups, and the relationship between PaCO2 and all-cause death in sepsis patients was studied using restricted cubic splines (RCSs). Results: Our study included 4898 sepsis patients, the hypocapnia (PaCO2 < 31 mmHg) and hypercapnia (PaCO2 ≥ 49 mmHg) groups were associated with the risk of death in sepsis patients using quintile grouping and the multivariate Cox model, with HRs of 1.12 (95% CI = 1.03–1.29) and 1.25 (95% CI = 1.10–1.41), respectively, when compared with the control group (37 ≤ PaCO2 < 41 mmHg). The relationship between PaCO2 and all-cause death in sepsis patients was U-shaped. Conclusion: The presence of hypercapnia and hypocapnia at the time of hospital admission will have adverse effects on all-cause death in sepsis patients.

Sepsis is one of the most common severe diseases in clinic. With the progression of the disease, it is very likely to occur acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Despite years of research, the mortality rate from sepsis-associated lung injury remains high. MicroRNAs (miRNAs) are a class of non-coding small RNAs with the function of regulating gene expression. In recent years, miRNAs have become a research hotspot in the field of biomedicine. Therefore, this review summarizes a large body of evidence implicating miRNAs and their target molecules in ALI/ARDS originating largely from studies using animal and cell culture model systems of ALI/ARDS. First, the pathophysiology and potential molecular mechanism of sepsis-associated ALI were briefly discussed at the cellular level, and the regulatory effect of miRNA on sepsis-associated ALI was summarized from the molecular mechanism so as to provide the possibility to find new targets for the treatment of sepsis-associated lung injury. Finally, some promising methods and some shortcomings of existing research are introduced.

Background: Sepsis is a life-threatening organ dysfunction caused by a maladjusted host response to infection (Sequential Organ Failure Assessment [SOFA] ≥ 2). PaCO2 is a blood gas that is commonly tested in hospitalized patients. Few studies have investigated how abnormal PaCO2 levels influence the prognosis of sepsis patients. Methods: A retrospective study was applied to data on sepsis patients extracted from the MIMIC-III public database and the results of their first PaCO2 examination after admission. The outcome measure was all-cause death within 90 days of follow-up. The patients were divided into five quintile groups, and the relationship between PaCO2 and all-cause death in sepsis patients was studied using restricted cubic splines (RCSs). Results: Our study included 4898 sepsis patients, the hypocapnia (PaCO2 < 31 mmHg) and hypercapnia (PaCO2 ≥ 49 mmHg) groups were associated with the risk of death in sepsis patients using quintile grouping and the multivariate Cox model, with HRs of 1.12 (95% CI = 1.03–1.29) and 1.25 (95% CI = 1.10–1.41), respectively, when compared with the control group (37 ≤ PaCO2 < 41 mmHg). The relationship between PaCO2 and all-cause death in sepsis patients was U-shaped. Conclusion: The presence of hypercapnia and hypocapnia at the time of hospital admission will have adverse effects on all-cause death in sepsis patients.

Sepsis is considered a life-threatening organ dysfunction resulting from a dysregulation of the body's response to the infection, a syndrome of physiological, pathological, and biochemical abnormalities caused by infection. The prevention and treatment of sepsis-related acute lung injury has become a hot spot in sepsis research in recent years. Neutrophil elastase (NE) is a multifunctional serine protease released by neutrophils cells, which can participate in the regulation of the inflammatory response in the body and directly affect the occurrence and development of inflammation. This article reviews the pathogenesis of sepsis-related lung injury and the mechanism of action, clinical application and prospect of neutrophil elastase inhibitor (NEI).